Journal of Allergy and Clinical Immunology (@jacionline) 's Twitter Profile
Journal of Allergy and Clinical Immunology

@jacionline

The Journal of Allergy and Clinical Immunology is an official publication of the American Academy of Allergy, Asthma, and Immunology.

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linkhttp://jacionline.org calendar_today16-04-2010 14:42:16

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Climate change is affecting outdoor and indoor allergen exposures, and diagnostic and treatment strategies should limit exposure and facilitate desensitization. An American Academy of Allergy, Asthma & Immunology Work Group Report shares 4 steps. Read on. bit.ly/4kP95bB

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Our understanding of the genetic etiology of allergic diseases has grown significantly in recent years. Read about key advances in the field, with a focus on common genetic variants that increase disease risk. bit.ly/45CWrIr

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Clinical trials of therapies for asthma and food allergy are complex, and there is intense interest in the development of biomarkers to predict natural disease history and response to therapy. Read a summary of a US FDA-hosted workshop discussion. bit.ly/4juKdVD

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The June issue of the Journal focuses on birth cohorts in allergy and immunology. A theme editorial summarizes key topics: the importance of investment in birth cohort studies, new best practices, the availability of administrative data, and more. bit.ly/4jCD71v

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Recent data have suggested that radon exposure is a potential novel, modifiable risk factor for asthma. New results identify important biologic disease pathways via biomarkers central to the exposure-outcome relationship. Learn more. bit.ly/3ZLZEBK

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How does allergic sensitization contribute to asthma? A study investigates the dynamics of temporal development of multiple component-specific IgEs (c-sIgE) and identifies c-sIgE networks associated with asthma. Read the Editors’ Choice findings here. bit.ly/4jyeCCA

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Why are some patients predisposed to uncontrolled persistent asthma? An Editors’ Choice paper identifies a sputum proteomic signature and pathways associated with future asthma exacerbations. The findings may facilitate novel approaches to treatment. bit.ly/4jGT4np

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Does physical activity affect asthma incidence? New data suggest that daily physical steps taken are lower in adults who develop incident asthma and may represent a modifiable risk factor. Read on. bit.ly/4kmK7Ra

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High doses of inhaled corticosteroids (ICS) can increase risks of adrenal insufficiency, and the underlying mechanisms are unclear. An Editors’ Choice paper associates specific metabolites and changes in pathways with adrenal insufficiency with ICS use. bit.ly/45bfYjg

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An obstacle in improving treatment outcomes for chronic rhinosinusitis with nasal polyps lies in an incomplete understanding of disease mechanisms. New data suggest that smoking-induced ferroptosis may exacerbate neutrophilic inflammation. Learn more. bit.ly/43LwkN7

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Patients with psoriasis have complex subsets of IL-17-producing T (T17) cells in their skin with protective or pathogenic functions. How are T17 subsets differently regulated by IL-23 versus IL-17A blockade? Read new data on treatment with risankizumab. bit.ly/4kAqLbC

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The distinction between generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP) has been a matter of debate. New data suggest that AGEP is a drug-induced variant of GPP. The issue also includes editorial commentary. bit.ly/4jDfx4y

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VAMP-7 mediates immune responses and its function in basophils remains undefined. Findings suggest that VAMP-7 is essential for basophil-driven chronic itch and acute itch flare in atopic dermatitis, and basophil-VAMP7 may offer a new treatment strategy. bit.ly/4dOpta9

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In honor of World Allergy Week 2025 and this year's theme of anaphylaxis, here's a link to a collection of JACI articles on the topic. bit.ly/4l9ZexZ #anaphylaxis #WorldAllergyWeek2025

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Tezepelumab is a mAb that inhibits thymic stromal lymphopoietin. An Editors’ Choice phase 2b study has evaluated tezepelumab treatment efficacy and safety in patients with chronic spontaneous urticaria refractory to second-generation H1 antihistamines. bit.ly/43NpZjY

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Cephalosporins are antibiotics used in surgery and to treat common infections, and IgE-mediated cephalosporin allergy affects 1% to 3% of the US population. A new study highlights an innovative method to reliably detect cephalosporin allergy. Read on. bit.ly/3HqwgL8

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The July issue of JACI is now online! Check it out here: jacionline.org/current This month's theme focuses on Endotypes in Allergy/Immunology. Read the Editors' Choice summaries from the June issue here (free to read/download): authors.elsevier.com/a/1lN0bKs2xLlkZ

The July issue of JACI is now online! Check it out here: jacionline.org/current
This month's theme focuses on Endotypes in Allergy/Immunology.

Read the Editors' Choice summaries from the June issue here (free to read/download): authors.elsevier.com/a/1lN0bKs2xLlkZ
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Prompt diagnosis of severe combined immunodeficiency is critical. A study explores variable factors including the impact of newborn screening associated with hematopoietic stem cell transplantation outcomes and overall survival in a multiethnic cohort. bit.ly/4402HJ4

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New data chronicle the clinical manifestations of a novel IRF8 variant, confirm its pathogenic nature, and specify a dominant-negative mechanism of action. The findings broaden the existing phenotype of IRF8 immunodeficiency. Learn more here. bit.ly/3FnUntq

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Accurate chronic rhinosinusitis (CRS) endotyping increases available therapeutic strategies and enhances clinical management. Read about the novel mechanisms associated with different CRS endotypes and new endotype-driven biologic treatments here. bit.ly/4ko5GA3