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Excited to share our latest publication on how PPIL2 promotes myeloproliferative neoplasms by degrading p53. Congratulations to our outstanding postdocs Pan Wang and Xu Han—who will soon launch his independent lab at Central South University in China. jci.org/articles/view/…

Early results in patients who had failed prior CAR T: → 81% overall response → 52% complete remission at 3 months → 3-day manufacturing turnaround This research from Carl June and team represents the first IL-18–secreting CAR T tested in blood cancer — and it may reshape

Combined #preprint and paper alert! Together with Sohrab Shah and Vivian E. Strong, MD, we have been exploring a fundamental paradox of cancer biology: how can the immune response both suppress and facilitate tumorigenesis? (It's a 2-parter!) biorxiv.org/content/10.110…

Fantastic Cancer Cell paper by Linghua Wang, MD, PhD MD Anderson Cancer Center revealing new biology in cancer-associated fibroblasts. cell.com/cancer-cell/fu…

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

Congratulations!

Great to see you. Awesome work as always.

It was an outstanding meeting with a number of rock star clinicians and scientists. Thanks for teaching us so much Teresa Palomero !

Great honor to the invited to share my thoughts at the “Meet the Expert” session re: how to make and use CAR T cell therapy. It was actually a precious opportunity for me to meet with the experts from the clinical side to think how we can work together to better help patients 💕

The Department of Oncology at University of Oxford is recruiting a Professorship sponsored by CRUK. A great opportunity for basic or translational biologists. Details here: my.corehr.com/pls/uoxrecruit…

🚨The *second* randomized clinical study to demonstrate significant survival benefit of T cell therapy Vs. standard of care for a relapsed/refractory solid cancer. Here, GEJ/gastric cancer using claudin 18.2 CAR-T. #Tecllpower thelancet.com/action/showPdf…

Congratulations!

Excited to share an update on our collaboration with Aviv Regev and Collin Stultz, led by Charles Comiter: predicting single-cell spatial transcriptomics from H&E images using SCHAF. New models, new datasets, and new discoveries. biorxiv.org/content/10.110…

Now online in Cancer Discovery: Divergent Evolution of Malignant Subclones Maintains a Balance Between Induced Aggressiveness and Intrinsic Drug Resistance in T Cell Cancer - by Terkild Brink Buus, Niels Ødum and colleagues doi.org/10.1158/2159-8… University of Copenhagen Research @skinUCPH

Congrats!

The Lymphoma Collection highlights the rapidly advancing field of lymphoma research by leveraging novel tools and techniques, uncovering molecular networks that drive oncogenesis and progression, and bringing innovative therapies to patients. brnw.ch/21wTwSY #18ICML

Now online! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment dlvr.it/TLT5Xf

It's 102°F/39°C in New Haven—but 30 international experts have braved the heatwave to join us at Yale School of Medicine for a 3-day workshop on chromosomal instability in cancer. Thank you to our workshop organizers, Roel Verhaak, Florian Markowetz, & Aurelie Ernst!

Thrilled to share our paper on how mitochondrial complex IV remodeling can modulate TAM functions and promote anti-tumor immunity! with Kamen Simeonov, MF Michieletto, Jasmine Wright, Rakesh, César de la Fuente, Andy Minn, JHMLab and those not on X! Out now in Immunity 🎉

Amazing evening with Willie Nelson and friends in Dallas! Keep on rocking! 😎