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Very excited to share our latest manuscript looking at metaplastic reprogramming and glycolytic dependency in GNAS mutant IPMNs! MD Anderson Cancer Center Gut Journal gut.bmj.com/content/early/…

I saw this stat yesterday in a Winter Fuel Payment thread & thought it was probably bollocks. So I checked... fullfact.org/economy/millio…

Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer ⁦Gastroenterology⁩ ⁦Andrew Waters⁩ ⁦Krushna Patra⁩ ⁦Dr. Nina Steele⁩ gastrojournal.org/article/S0016-…

Incredible work in Cell from Rong Fan Zhiliang & colleagues Yale Cancer Center - they took the biggest Achilles heel of formalin fixed archival tissues & turned it on its head for comprehensive spatial RNA profiling. cell.com/cell/fulltext/…

Dr. James Farrell of Yale Digestive Diseases published a review on the current state of clinical care & research for pancreatic cysts in NEJM. Learn more about research around pancreatic cysts & why he is inspired to learn more about this field in the Q&A below. medicine.yale.edu/internal-medic…

🥁Out today in the October issue of Cancer Discovery: ⭐️The Epigenetic Hallmarks of Cancer⭐️ - by Manel Esteller, Mark Dawson, Cigall Kadoch, Feyruz Rassool, Peter Jones, and Steve Baylin doi.org/10.1158/2159-8…

Interesting findings from #PancreaticCancer screening ⭐️Incidental findings noted in 84.4% with MRI compared to 20% with EUS (RR=4.9; P < 0.001) ⭐️Potentially serious incidental findings found in 16.7% patients with MRI compared with 6.7% with EUS (P = 0.005) Mohammad Bilal, MD

Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre study - eBioMedicine thelancet.com/journals/ebiom…

Wonderful working with Apostolos Gaitanidis and the team on this: A Genome-wide Association Study Reveals a Novel Susceptibility Locus for Pancreas Divisum at 3q29 - ScienceDirect sciencedirect.com/science/articl…

Pancreatic cancer arising in intraductal papillary mucinous neoplasms (IPMN): emerging data warrants further research ⁦BJS⁩ academic.oup.com/bjs/article/11…

#OpenAccess in Journal of Surgical Oncology Screening high-risk individuals for #PancreaticCancer leads to earlier detection & significantly improved survival. Patients in surveillance programs were more likely to be diagnosed at stage 0 & showed better long-term outcomes post-surgery. #pancsm

For researchers interested in the functional basis of new onset #diabetes occurring in the context of #PancreaticCancer, a preclinical study nominates sorcin (SRI) as a candidate that might cause paracrine beta cell dysfunction & hyperglycemia. nature.com/articles/s1227…

⚕️Pancreatic cysts are seen in up to 40% of cross-sectional abdominal imaging studies! ⚕️The vast majority represent branch duct IPMNs ⚕️ What is the utility of EUS for evaluating IPMNs? Check out our latest study! authors.elsevier.com/a/1kIl653tctIB…

Acute pancreatitis and IPMN 🍇 a dangerous association! ⚡️ 800 resected / 20% had AP (other causes excluded) 🎯 AP associated with HGD (OR 2) 💡 Careful! Is it TRUE AP!? Gallstones 🥑 excluded?! Then you found a WF... 👍 surgjournal.com/article/S0039-…

New JAMA Network Open study by Ignacio Garrido-Laguna in collaboration with Foundation Medicine Flatiron Health on the impact of KRAS allelic status on outcomes in #PancreaticCancer. In ~2500 patients, those with wild type KRAS have the most favorable outcomes followed by G12R and then

Use of aspirin 💊 to lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus 🇭🇰 15 years / 350k pts / 0.2% died of PDAC 💡 Aspirin associated to ⬇ mortality, cancer related and PDAC 🍭 Indicated for T2DM!? 🧐 gut.bmj.com/content/early/…

New paper on spatial transcriptomics (using GeoMx and CosMx platforms) of Intraductal Papillary Mucinous Neoplasms (IPMNs), precursor lesions of #PancreaticCancer. BY Yasmin Hernandez-Barco, MD & colleagues MassGeneral News This study identifies the transcriptomic features of

Thank you for highlighting our study Anirban Maitra! It was a long-time collaborative effort across our Pancreas program.

Clearing of mutant KRAS in ctDNA with RMC-6236 monotherapy in 2nd line & beyond metastatic #PancreaticCancer. >90% of patients with either G12D or G12X see a greater than 50% reduction in mutant allele fraction from baseline, & nearly 50% have cratering of mutant KRAS. #GI25

💫Highlights from @HPBjournal: Optimal cancer risk treashold (CRT) for BD-IPMN 🍇 🇺🇸decision model Base case: surgery 🔪 preferred over surveillance 🤔 📈Optimal CRT depends on age👵👴 and compl risk @ihpba Prof Steve Wigmore Greg Sacks hpbonline.org/article/S1365-…