🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Our aging manuscript is finally out in the November issue Cancer Immunology Research! Check out if you are interested in understanding how aging impact anti-tumor immunity and response to anti-PD1 ICB! #aging #Tcell

Excited to share IMMClock—an innovative single-cell immune aging clock that offers an unprecedented look at immune aging at the single-cell level! This tool opens new doors for understanding and potentially reversing immune aging. 🧵⬇️ biorxiv.org/content/10.110…

Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence, including a female-specific cytotoxic CD8+ T cell subpopulation Marta Melé Aida Ripoll-Cladellas Maria Sopena Rios papers.ssrn.com/sol3/papers.cf…

CD38 modulates cytokine secretion by NK cells through Sirt1/NF-κB signaling pathway nature.com/articles/s4159…

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity Nature Aging nature.com/articles/s4358…

📢 Early-career cancer researchers! We're holding elections to join the AACR Associate Member Council ‘25-‘28. The deadline was extended until 12/02. If you are interested, please reach out: aacr.secure-platform.com/a/page/amc-ele… #AACR #AACRAMC

Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps nature.com/articles/s4146…

Dynamic trajectories of human peripheral immune cells from birth to old age Nature Immunology nature.com/articles/s4159… nature.com/articles/s4159…

Fantastic work! Congratulations Jaime L. Schneider, M.D., Ph.D. 🎉

ImmuneLENS characterizes systemic immune dysregulation in aging and cancer | Nature Genetics nature.com/articles/s4158…

Age-dependent cytokine surge in blood precedes cancer diagnosis pnas.org/doi/10.1073/pn…

Identification of cellular senescence-associated genes for predicting the diagnosis, prognosis and immunotherapy response in lung adenocarcinoma via a 113-combination machine learning framework link.springer.com/article/10.100…

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging Nature Aging nature.com/articles/s4358… Mittelbrunn Lab Gonzalo Soto-Heredero

#ScienceSaturday ❓ How does aging affect the immune cells infiltrating tumors? ➡️ As we age, our circulating blood and immune cells can develop mutations called clonal hematopoiesis of indeterminate potential (CHIP). ➡️ Analyzing nearly 50 thousand cancer patients,

Excited to share our lab’s first review about which cell types in the body can be the target to combat aging! We summarized ~100 single-cell studies of aging tissues, identifying aging-associated cell types strongly depleted or expanded across the body: shorturl.at/Oi3W8

An antibody directed to the NAD-degrading enzyme CD38 in mice restores metabolic fitness, improves cognitive performance & lowers neuroinflammation nature.com/articles/s4146…

Huge congratulations Peter Georgiev and Sheila from Sharpe/Haigis labs!!!! 🎉🎉🎉🎉

Chronic NAD deficiency causes mitochondrial DNA to be released into the cytoplasm, which activates an inflammatory response onlinelibrary.wiley.com/doi/pdf/10.111…

When the next generation of cancer immunologists meet those who walked the path. Thank you all the mentors for showing us the light & path forward 🙏🙏🙏 #cancerimmunology #mentorship

#aging #immune_aging NEW PREPRINT FROM Artyomov&Randolph labs: How mouse age-associated GZMK+ CD8 Taa cells develop and what are correct surface markers for them biorxiv.org/content/10.110… Among other things we - Using OT1-Rag2ko mice explicitly show the TCR dependence and yet