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I wrote down my rules on how to Science. I hope you find it useful!

Very pleased to present our latest work deciphering mechanisms of actin bundle construction by fascin from the Angstrom to the micron scale. A team effort by Rui Gong and Matthew Reynolds, and a great collaboration with Bidone Lab. bit.ly/3uorbNn

Super small tetrazines light up the carbs on bacterial cell wall like never before. Mac invasion and So many applications to come; Fantastic collaboration with Fox Lab at UD led by Ashlyn Hillman Stephen Hyland Dr. Kimberly Wodzanowski UD Research Univ. of Delaware Graduate College UDelaware_CBI

I'm thrilled to share that I've been awarded an NIH NRSA F32 fellowship through the NCI to support my postdoctoral studies at Rockefeller! Beyond thankful, and looking forward to tackling unsolved problems at the interface of chemical and cancer biology over the next three years

VVD-214/RO7589831: A Covalent Allosteric WRN Helicase Inhibitor Stemming from Chemoproteomics Screening This article highlights the discovery of VVD-214, its pharmacology, WRN as a synthetic lethal target, and Vividion's chemoproteomics platform. Link | drughunters.com/3JF1MTj

The advent of AlphaFold3 could be an unprecedented boon for drug development. Computational biologist JK Lyu discusses the pros and cons of the tech, and his work analyzing the algorithm, published in Science Magazine today. rockefeller.edu/news/35839-ai-…

Calvin Leonen is a Filipino-American postdoctoral scientist from the island of Guam. Calvin's research in Hironori Funabiki's lab centers around the question of self versus non-self recognition by an innate immunity sensor that binds to DNA. #AANHPIHeritageMonth

Congratulations to Rockefeller’s #classof2024, here’s to your next adventure! #PhDone 🔬🍾🧬

Huge honor and pleasure to be with Rockefeller University grads and faculty. A jewel of an institution, and some mighty students. Go forth and make #science for people and the planet.

The 20th annual TPCB Chemical Biology Symposium will be on August 14th and feature keynote speakers Heeseon An An Lab, Carlos Bustamante The Bustamante Lab, Jonathan Long Long Lab and Yamuna Krishnan @KrishnanYamuna! Register for free: bit.ly/TPCB-2024

Big Nature paper this week on improved lifespan (in mice!) using an antibody to block IL11 Old mice without IL11 even look healthier 🧵

Direct RAS inhibitors turn 10 -- In a Comment, Jonathan Ostrem, Ulf Peters, and Kevan Shokat provide a personal perspective on their initial report of KRAS inhibitors and the decade of discoveries that followed. Read it here rdcu.be/dPl36

PI back at the bench for the one thing he still can do better than anyone else

We are pleased to share our latest preprint on bioRxiv! Led by graduate student Lauren Vostal, we use chemical proteomics to profile VCP-DUB interactions in living cells. We identify DUBs that bind the entry, exit, or both sites of VCP's central pore. biorxiv.org/content/10.110…

My lab is hiring for two new postdoc positions! It's a very exciting time to join, especially if you love single-molecule approaches. Please RT! jobs.rutgers.edu/postings/234803

Happy to share this work from my rotation in Katya Vinogradova ‘s lab! This was my first experience preparing proteomic samples and a deep dive into the power of cysteine ABPP to discover new biology. Thank you to everyone who helped bring this together!

Incredible scenes of a killer T-cell destroying an ovarian cancer cell many times its size 👾💥

Vostal et al Kapoor Lab Rockefeller University report two structures of complexes formed by VCP, an unfoldase, & VCPIP1, a deubiquitinase, & suggest that VCPIP1 is poised to cleave #ubiquitin from protein substrates that translocate through VCP’s central pore hubs.la/Q03bV3G00

Worst take of all time

I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces. biorxiv.org/content/10.110…