Thrilled to share our characterization of the human tyrosine kinome. Try out the public website: kinase-library.mit.edu/home Wonderful collaboration with Cantley Lab Turk Lab YaffeLab. Many years of work led by Jared Johnson! nature.com/articles/s4158…

NEWS: We are delighted to announce that a new lost story by Terry Pratchett has been found. You can read more about Arnold, the Bominable Snowman, here: terrypratchett.com/news/another-l…

Very sad to hear this news. Jim Simons’s support has had an enormously positive impact on Cold Spring Harbor Laboratory and on my own career.

Very surprised and excited to watch the Aurora Borealis from Cold Spring Harbor Laboratory and Bayville, Long Island, NY. With Sanchari Ghosh

Our work on a one-to-one mapping between deep network units and neurons in the fruit fly visual system is published! dynamic stimuli, interesting behavior, a full connectome, deep networks---it's an exciting time to be fruit fly modeling! nature.com/articles/s4158… nature

If you’re interested in what the last few years have taught us about the process of splicing, check out our latest review!Congratulations to my co-authors Hope Eliana Merens @karine_choquet Autum Baxter

Excited to share new work on “Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion.” We extend Score Entropy Discrete Diffusion to regulatory DNA! Work led by anirban sarkar. paper: biorxiv.org/cgi/content/sh…

Do you really need to spread plasmid libraries on mountains of plates to get uniform growth, or can you just dump them in a flask and call it a day? We make huge plasmid libraries in the de Boer Lab, so we tested whether culture method really matters. 1/ biorxiv.org/content/10.110…

I never did understand why people plate their MPRA/DMS libraries out (we've been using liquid culture exclusively since 2008). Glad to see a systematic investigation of this.

Our latest - how does DNA sequence dictate the chromatin response to changing transcription factor levels? 1/n biorxiv.org/content/10.110…

Hey folks at UC San Francisco I am hosting Ben Lehner on Monday to give a talk on rock hall 2-3 it will surely be great! He will surely be discussing his mind blowing biophysical mutational scanning! Be there or be square! QBI UCSF Biophysics UCSF School of Pharmacy UCSF Bioengineering & Therapeutic Sciences

NumPy 2.0 will be released on June 16, in exactly 2 weeks from today. Exciting new features and performance improvements ... and also *breaking API and ABI changes*. Please ensure your Python packages and code are ready for this release! See numpy.org/news/#numpy-20… for more info.

Last year, we discovered that fluorescent proteins get a little dimmer in modest magnetic fields (e.g. GFP gets ~1% dimmer in ~10 mT). MagLOV gets a LOT dimmer. Here's ΔF/F ≥ 75% in live E. coli! It works purified, and in mammalian cells too. andrewgyork.github.io/gfp_magnetoflu…

This is one of the most delightful developments in FPs I’ve seen ❤️❤️❤️ Super excited to see this finally out and super curious to see what all the innovative applications will be!

We are hiring a lab manager/research assistant! More details and how to apply here: bintulab.com/2024/06/01/hir…

Calling historians of biology! Research & travel funds are available to scholars at all career stages. Note the upcoming July 31 deadline for our $5000 Sydney Brenner Fellowships. Travel-grant applications may be submitted at any time. More information: cshl.edu/education/cent…

So excited for their next adventures, so sad to see them go. Congratulations to our very first PREP cohort on an amazing year. We know you are destined for great things!!

Very proud that SQUID is now published in Nature Machine Intelligence! Nature Machine Intelligence View only link (no subscription needed): rdcu.be/dLuZe Full link (w/ subscription): nature.com/articles/s4225… Evan Seitz Justin B. Kinney David M. McCandlish (Thanks to reviewers for feedback)

Excited to launch our cloud-based image analysis platform today at nimbusimage.org! Analyze and interact with your data, all in the browser. Follow sign-up instructions to request an account.

NAISys - NeuroAI Meeting at CSHL **** ABSTRACTS DUE July 12 **** Blake Richards Doris Tsao