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438 new Covid deaths reported yesterday. Yet today Boris Johnson scraps Plan B measures. A prime minister who prioritises saving his own political skin over the actual deaths of others.

My piece on endemicity for @nature. I wrote about the use and misuse of this term, the assumptions it is often associated with, and how we can help shape the years to come. nature.com/articles/d4158…

Yesterday: tackling the Covid hospital backlog Today: scrap* Covid isolation for infectious people, thereby increasing the number going in to hospital+.

The data that supports abandonment of self-isolation after a positive test, announced by Boris Johnson today for the UK ft.com/content/0f84d9…

THREAD: I keep being asked when we can go "back to normal" or "like it was before". My personal thoughts: We've added a new disease to our population, more infectious and more severe than flu. The world pre 2020 no longer exists - we may want it to, but it just doesn't. 1/13

On this #NationalDoctorsDay want to give a shoutout to all the drs doing research on #RenalOncocytomas and #SmallRenalMass(es) starting w/@HopkinsNucs Michael Gorin, M.D. Mohamad Allaf Phillip Pierorazio Brian Shuch, MD Andres Correa Alexander Kutikov MD Joana B Neves Hannah Warren Sure I forgot some

Aaaand the NEST Twitter account is live! Please follow for research news and updates from Maxine Tran team Royal Free London Specialist Center for #KidneyCancer Debra Gottsleben m Joana B Neves Ravi Barod Ben Challacombe BAUS

Genomic initiation occurs early, on average within the first few years of life. Neutral evolution follows, with an absence of secondary driver events.

SDH deficient RCCs appear to have originated from macula densa cells. These cells play key sensory and regulatory functions, similar to the function of cells that give rise to the neural crest derived SDH deficient pheochromocytomas and paragangliomas.

One marker of macula densa cells, PAPPA2, appears retained in all SDH deficient RCCs. As diagnosis through morphology and immunohistochemical staining is not always conclusive, positive PAPPA2 staining may prove a valuable adjunct. #gupath

We saw a striking lack of immune infiltration in all of these tumours, possibly via the combined effects of PAPPA2, TGF-b and PD-L1 expression. In this context, traditional immune checkpoint inhibitors alone may fail, requiring tailored combination therapy.

Very proud to be part of this project!

I am pleased to announce our latest paper. We report results from single cell RNA and TCR sequencing, alongside spatial RNA and genome sequencing across different regions of kidney cancers: cell.com/cancer-cell/fu…

Massive congratulations to ⁦Maxine Tran⁩ - the second woman to be Professor of Urology in the UK! 💃🏼🎉💃🏼🎉💃🏼Fantastic work in renal cancer ⁦UCL Div of Surgery⁩ ⁦Royal Free London⁩ ⁦The Royal College of Surgeons of England⁩ ⁦Women in Surgery⁩ ⁦Ravi Barod⁩ ⁦UCL⁩ ⁦

huge congratulations for my friend, colleague and inspiration for 20 years…. Maxine Tran for her thoroughly deserved professorship in kidney cancer UCL Div of Surgery … wonderful to celebrate with mentors Tim O'Brien and Patrick Maxwell and colleagues past, present and future 💪🏽

Looking forward to sharing results of the feasibility NEST trial ECIO & delighted to receive a poster award! Thank you to all our patients Royal Free London National Institute for Health and Care Research NEST

Food security is a health issue. This should be top of the Minister of Health and CMO's agenda. Hungry children in the UK is an obscenity.

So exciting to see MULTI-MIBI Trial expand to more sites - the first multi-center trial of Sestamibi SPECT/CT!🥇 Let’s hope the future for patients with benign renal oncocytomas avoids invasive tests + surgery Nick Campain Professor Tze Min Wah Iosif Mendichovszky Michael Gorin, M.D. Debra Gottsleben Maxine Tran

congratulations Maxine Tran Joana B Neves and UCL Royal Free London team on successfully demonstrating that a cohort embedded RCT design is feasible in investigating interventions to treat #kidneycancer a novel way to improve recruitment to surgical RCTs sciencedirect.com/science/articl…

Articles in Press: Nephron Sparing Treatment (NEST) for Small Renal Masses: A Feasibility Cohort-embedded Randomised Controlled Trial Comparing Percutaneous Cryoablation and Robot-assisted Partial Nephrectomy buff.ly/49QRnA8 #UroSoMe #Medtwitter