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IL-13 signaling-regulated beige adipocyte function may play a predominant role in modulating metabolic homeostasis rather than in thermoregulation in mice Journal of Clinical Investigation jci.org/articles/view/…

How can we enhance the efficacy of CAR T cell therapy for HIV? Anjie Zhen & team show rapamycin reduces HIV-mediated chronic inflammation and T cell exhaustion, delaying viral rebound and reducing viral reservoir in mice: jci.org/articles/view/…

An exciting finding for the TB community! Monica Dallmann-Sauer Erwin Schurr & team Research Institute of the MUHC (The Institute) show people with HIV who are resistant to infection from Mycobacterium tuberculosis display activated alveolar macrophages & increased alveolar poly-cytotoxic T cells: jci.org/articles/view/…

HoxBlinc: A key driver of chromatin dynamics in NUP98 fusion-driven leukemia: jci.org/articles/view/… Jian Xu & WeiDu UPMC Hillman Cancer Center provide a Commentary on Karina Hamamoto et al. (jci.org/articles/view/…)

Targeting lactylation and the STAT3/CCL2 axis to overcome immunotherapy resistance in pancreatic ductal adenocarcinoma: jci.org/articles/view/… Min Li & team OU College of Medicine provide a Commentary on Kang Sun et al. (jci.org/articles/view/…)

Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype? jci.org/articles/view/… Todia P. Setiabudiawan et al. provide a Commentary on Monica Dallmann-Sauer et al. (jci.org/articles/view/…)

Merkel cell carcinoma is an aggressive neuroendocrine skin cancer with high rates of metastasis. Megha Padi & team University of Arizona Cancer Center now show pyrvinium pamoate has antitumor activity through multiple pathways in pre-clinical models: jci.org/articles/view/…

Another reason to sleep! Geoffrey Canet et al. Université Laval show wakefulness body temperature upregulates neuronal tau secretion and correlates with tau levels, highlighting the importance of sleep and thermoregulation in Alzheimer’s disease. jci.org/articles/view/…

Antibodies that suppress tumor growth in a challenging cancer! This issue’s cover features work by William R. Sellers & team Broad Institute on the identification of biparatopic FGFR2 antibodies that are effective against FGFR2 fusion-driven cholangiocarcinoma.

Here, treatment with a GLP-1R agonist effectively alleviated hyperphagia, body weight gain, improved glucose tolerance, and circulating metabolic hormones in BBS5-/- mice jci.org/articles/view/… Journal of Clinical Investigation

A fast, and accurate swab-based test for fungal pneumonia! Jay K. Kolls Tony Hu & team Tulane University describe an oropharyngeal swab CRISPR assay that detects Pneumocystis jirovecii pneumonia with high sensitivity in infants: jci.org/articles/view/…

New in Journal of Clinical Investigation We identified GLP-1 receptor therapy as a promising Bardet-Biedl Syndrome #BBS treatment. 🔬 We uncover new mechanisms driving metabolic dysfunction in BBS & point to new therapy targets. 🔗jci.org/articles/view/… 🧠🧬💉 #GLP1 #RareDisease #Science

What causes immunotherapy resistance in head and neck cancers? Guangyong Peng and coauthors WashU Medicine review cell- and etiology-specific mechanisms and recent approaches to improving outcomes in HNSCC patients: jci.org/articles/view/…

The potential for off-the-shelf natural killer cells vs pancreatic cancer jci.org/articles/view/… "With striking response rates observed in all models tested, and with 100% survival at day 80 being reported, the remarkable efficacy of PSCA CAR_sIL15 iNKT cells is compelling."

some GD T cell lymphomas are addicted to JAK-STAT signaling and relapse with new JAK-STAT mutations, much like melanomas to BRAF inhibitors. may represent new approach to treating these aggressive diseases. Journal of Clinical Investigation jci.org/articles/view/…

An off-the-shelf cell treatment that suppresses pancreatic cancer in mice! Dai et al. show PSCA CAR_sIL15 NKT cells have anti-tumor activities without causing systemic toxicity or graft-versus-host disease in pancreatic ductal adenocarcinoma models: jci.org/articles/view/…

Journal of Clinical Investigation .We have uncovered "impaired" and "emergent" insulin signaling defects in T2D liver. Is "emergent" signaling the basis of "selective insulin resistance"? Thank you, Kahn, Matthias Mann Lab, Cantley labs. jci.org/articles/view/…

Tapping the Chilean soapbark tree for an HIV vaccine component Darrell J. Irvine & team show the saponin monophosphoryl lipid A nanoparticle adjuvant enhances adaptive immune responses against HIV in a dose-dependent manner in non-human primates: jci.org/articles/view/…

Developing cell-based therapies for pancreatic ductal adenocarcinoma: jci.org/articles/view/… KocherLab Prof Kocher Rachel Fincham Queen Mary University of London provide a Commentary on Dai et al.(jci.org/articles/view/…)

Transient pain and long-term gain: Adjuvant dose directs immune memory: jci.org/articles/view/… Pabitra B. Pal & Smita S. Iyer University of Pittsburgh provide a Commentary on Parham Ramezani-Rad et al. (jci.org/articles/view/…)