🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Dan Landau Federico Gaiti Ally Hawkins Mariela Cortés López If y'all got sequences of mis-spliced ORFs - provided they produce changes in polypeptide sequence - you can add proteomics to the -omicses you already have. de novo sequencing of proteins is non-trivial, but if you can make a fasta file for searching, then it's quite doable.

Adult low hypodiploid #acutelymphoblasticleukemia emerges from pre-leukemic #TP53-mutant #clonalhematopoiesis, by KIMR et al. bit.ly/3Xne5IU Institut de Recherche Saint-Louis (IRSL) #LeuSM #CancerGenomics #ALL #leukemia

Insighful work inspired by a BMF syndrome, congrats Vijay

Clonal hematopoiesis is an expansion of blood stem cell clones caused by mutations in a recurrent set of genes. Our paper on factors mediating expansion of these mutant clones is published today. nature.com/articles/s4158… Thread below...

Delighted to share our new approach for high fidelity sc genotyping combined with scATAC - called GTAC! Do check it out! We love it. Great collaboration with the Hughes and Davies labs also in the WIMM. Credit to Sven, Asger, Angus and all co-authors. cell.com/cell-stem-cell…

What causes #ageing to our blood🩸? Read our latest study Molecular Cell showing 🧬 DNA damage from aldehyde metabolites drive blood stem cell ageing via a p53 response. cell.com/molecular-cell… Wonderful collaboration of KJ Patel CAM-OX traveller and Bertie Gottgens labs! More below:

Happy to share our last paper published today in Cell Host & Microbe showing that network of gut #microbiome, #virome and #metabolome associate with circulating T cell profiles and relapse risk after #alloHSCT #bmtsm cell.com/cell-host-micr…

Thrilled to speak at @ThemaSaintLouis kick-off symposium in Paris on Sep 9-10, hosted by Hugues de Thé & Jean Soulier! Can’t wait to reconnect with colleagues like Nina Cabezas-Wallscheid, Andreas Trumpp HI-STEM - Cancer and Stem Cells in Heidelberg, Andy Lane, paresh vyas, Ruud Delwel & more! bit.ly/4cws1rL

Finally able to share our work “Germline ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition” in full (well at least pt1). It is out as a First Edition preprint in Blood ashpublications.org/blood/article/…

My colleague Fernanda Gutierrez-Rodrigues giving an excellent talk at #ESHBMFS2024 on the clinical implications of clonal hematopoiesis in #telomere biology disorders 🧬; dependent on specific mutation with U2AF1, TP53, and chr1+ associated with #MDSsm and #AMLsm. @nih_nhlbi ESH (Haematology)

After the meet the expert session, #ESHBMFS2024 continues with brief oral communications of top scoring abstract. Great discussions about Vexas syndrome, lentiviral mediated therapies in FA, impact on interferon gamma activity on graft failure and GVHD. #ESHCONFERENCES #BMFsm

How has our understanding of pathophysiology in aplastic anemia evolved? A fascinating presentation by Jaroslaw Maciejewski from Cleveland at #ESHBMFS2024. Chairs Austin Kulasekararaj and Regis Peffault De Latour #ESHCONFERENCES #BMFsm