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After a long wait, extremely happy to see this work out nature.com/articles/s4155… WHATACOMPLEX! great collaboration with amazing group of people in Hiro Suga's lab Tokyo 東京大学 大学院理学系研究科 化学専攻　理学部化学科 Chris S lab Schofield Group and Akane Kawamura Newcastle University link here: rdcu.be/dcKJe

We're looking for a PROJECT SCIENTIST to join the C-GEM team! You will play a key role in the design, synthesis, structural analysis, evolution, and/or application of next-gen materials and biologics prepared in cells. Please share! Apply: aprecruit.berkeley.edu/JPF03947 #chemjobs

Inspiring! “The many layers of aaRS biology”

Such a great opportunity to reunite with the Söll family AARS2023 with Michael Ibba @HeinemannIlka Oscar Vargas Rodriguez Jeffery Tharp and others

It’s a wrap! Thanks for joining us and making #AARS2023 an inspiring meeting! IUBMB

Please join us tomorrow October 6th at 3:30 PM in R4 101 for an amazing seminar from our invited guest Dr Jorge Cantù Jorge A Cantú This is a great opportunity to support and celebrate Hispanic Heritage Month!

Another very cool application of our split RNAP biosensor technology from the Saito lab in Kyoto. Split RNAPs + split antibodies = intracellular detectors for everything! Bonus fact - the first author (Shodai) will be doing the team soon! nature.com/articles/s4146…

Breakthrough**tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut Puglisi Labs Jeffery Tharp Sergey Melnikov Trushar Patel, PhD, DSc 🇮🇳🇨🇦 @NatalieKrahn13 Yale MB&B StanfordCryoEM academic.oup.com/nar/advance-ar…

Excited to share our recent efforts in developing tRNA-based therapeutics. This was a rather large effort…..“Optimization of Anticodon Edited Transfer RNAs (ACE-tRNAs) Function in Translation for Suppression of Nonsense Mutations” biorxiv.org/content/10.110…

Happy to share VADER2.0 for directed evolution of tRNAs in mammalian cells, which enabled simultaneous randomization/selection of much larger and smarter pyrrolysyl-tRNA libraries to identify highly efficient variants!

1/3: New paper alert! A collaboration between our faculty, Drs. Scott Aoki, Jonah Vilseck, and Wen Zhang, is now on BioRxiv! This work, led by Murphy Angelo, used λ-dynamics to predict RNA modification interactions with proteins. biorxiv.org/content/10.110…

Derda Lab is taking a fresh look at molecular discovery: why always start from zero, if you can start from one? Check out the paper led by Kejia Yan Kejia Yan on late stage reshaping of pre-discovered molecular landscapes, now on BioRxiv doi.org/10.26434/chemr…

Bacteria have an astonishing ability to put their life on pause in the face of stress and starvation by entering a state of dormancy. Here, we discover one aspect of this remarkable self-preservation strategy: nature.com/articles/s4158…

Another chapter in the VADER saga: Directed evolution of the bacterial leucyl-tRNA in mammalian cells for improved noncanonical amino acid mutagenesis, led by the amazing Rachel Huang. She defends her thesis next month! biorxiv.org/content/10.110…

Biochem Seminar day! Today we welcome Dr Lei Wang, Professor of Pharmaceutical Chemistry at UCSF, who will speak on “New Covalent Bonding Ability for Proteins”. 4pm, MS B26, cookies and coffee provided!

This could have save me A LOT of plating.

ncAAs can endow proteins with new activities, but their incorporation efficiencies during translation can be poor. Today in Nature Biotechnology, we report that altering mRNA codon usage can improve incorporation efficiency, yielding proteins with up to 3 ncAAs! nature.com/articles/s4158…

New in JBC press: "Scientists' findings suggest that nucleobase-specific hydrogen bonds by SRY are critical for specific DNA binding, bending, and transcriptional activation." Learn more: jbc.org/article/S0021-…

Perfect timing! our latest paper on #tRNA engineering is now published, coinciding with the ongoing #tRNA2024 conference. This publication is the result of a phenomenal team effort with Jeffery Tharp academic.oup.com/nar/article/do…

Congratulations to Kejia Yan Kejia Yan the lead on the most complex and comprehensive Journal of the American College of Surgeons (JACS) publications from Derda Lab to date. Big thanks to 48Hour Discovery and Dustin Maly Lab for their contribution. See "late stage reshaping" paper at doi.org/10.1021/jacs.4…