The Department of Biological Sciences is bringing quantitative biology to the forefront. cmu.edu/mcs/news-event…

Checkout the latest work from the lab online today in Molecular Cell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by Nancy De La Cruz Prashant Pradhan and Reshma T Veettil .

Our latest work is now published in Molecular Cell! We discovered new RNA-binding zinc finger proteins and demonstrated their functions in RNA splicing, stability, and polyadenylation. Congrats to 1st author @MayaGosztyla and our fantastic collaborators. cell.com/molecular-cell…

An RNA-centric view of transcription and genome organization. In this review for our #RNA focus issue, Jonathan Henninger and Richard Young highlight the important roles of RNA in transcriptional regulation. dlvr.it/TF58dc

Excited for 1st paper from our lab - led by the amazing Ryan Krueger in collab. with Brenner Group. How do we design intrinsically disordered proteins (IDPs) that lack a stable structure and are continuously shapeshifting for different target functions? doi.org/10.1101/2024.1…

Genetic evidence for functional specificity in biomolecular condensates: nature.com/articles/s4157… Free read only copy: rdcu.be/dXDvY Ben Sabari @idpsig Hyman Lab @PappulabWashU Phase Transition Papers Nature Reviews Genetics MPI for Molecular Genetics #Condensates #IDR

The Department of Biological Sciences will host virtual information sessions about master's programs and Ph.D. program Oct. 28-Nov. 18. Learn more about the department and its programs: apply-dc-mcs.mcs.cmu.edu/portal/mcs-bio…

It was a pleasure working with Denes Hnisz and Hyman Lab on this article for Nature Reviews Genetics where we review results from experimental and disease genetics that together provide insights into cellular functions and molecular specificity of condensates: nature.com/articles/s4157…

Pre-print alert! With experimental collaborators at the Young lab (MIT), we investigate how (i)active rRNA transcription maintains the size, spacing, and number of nucleolar fibrillar centers, (ii) the consequence of this arrangement on rRNA processing. biorxiv.org/content/10.110…

Our lab is very grateful for the support from the Kaufman Foundation & The Pittsburgh Foundation! We are excited by the research that this support enables, studying fundamental roles for RNA molecules in regulating their own expression. kaufman.pittsburghfoundation.org/2024KaufmanAwa…

I am excited to share our review, published online today Nature Reviews Molecular Cell Biology. Pilong Li, Gaofeng Pei, Heankel Lyons, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…

So fortunate to have Mike Rosen as the Keynote speaker at our 2nd Annual Steel City Condensate Symposium. The day was filled with great science from biologists, chemists, physicians, and computer scientists from CMU, Pitt & NYU. Condensates continue to surprise us in many ways!

Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. nature.com/articles/s4155…

Final version of our L2G paper is now published at Transactions on Machine Learning Research! Kudos to Wenduo Cheng for leading this work. Paper: openreview.net/forum?id=5NM4g…

Deadline coming up for this fantastic meeting!

Happy to see this coming out at JCB!

I am extremely grateful for the support from the Samuel and Emma Winters Foundation! This award directly supports our research on targeting RNA sequences as potential therapies in multiple disorders, including cancer.

Make an impact in #Pittsburgh! Ferra Executive Search, in partnership w/ Carnegie Mellon University, is seeking the Head of the Department of Biological Sciences. Learn more: apply.interfolio.com/174916  #STEMLeadership #HigherEd #LifeSciences #AcademicJobs #jobs #FerraSearch #BiologyChair

⏰ Final call! Talk submission for #GenReg26 closes tomorrow, 17 October - don’t miss your chance to be part of the programme. Check out the initial schedule & explore discounts and grants available👉 bit.ly/4eWDxin Flyer below with all the key info! GardiniLab