Excited to see our modeling paper on myeloid-derived suppressor cells out now in Cancer Immunology Research! #julialang #MDSCs

So thrilled to announce our publication on math modeling of myeloid suppression! Thank you Adam MacLean and Jesse Kreger it’s been so awesome building this collaboration, I am learning a ton and we are going to do great things together! USC Norris Comprehensive Cancer Center

This paper excites me since it's a stochastic delay differential equation (SDDE) mixed with global sensitivity analysis (via Morris method) and Bayesian inference. It's really a showcase of #julialang #sciml tools coming together. Kudos Adam MacLean ! aacrjournals.org/cancerimmunolr…

Published in Cancer Immunology Research - AACR, Drs. Evanthia Roussos Torres, MD, PhD & MacLean demonstrated importance of MDSC dynamics as a crucial predictor of outcomes in breast-to-lung metastasis and a possible therapeutic target. Link: aacrjournals.org/cancerimmunolr… USC Dornsife College of Letters, Arts & Sciences Keck School of Medicine of USC

Thanks USC Norris Comprehensive Cancer Center for highlighting our paper with this mini explainer on why you should care about myeloid suppressor cell dynamics (and model them!) w Jesse Kreger USC Dept. of Quantitative & Computational Biology USC Dornsife College of Letters, Arts & Sciences Evanthia Roussos Torres, MD, PhD @KeckMedUSC

This week in #MathOnco 253 -multi-scale modeling -fractional differential equations -predictive modeling -heterogeneity -nutrient availability Art by: Jesse Kreger (Jesse Kreger) and Adam MacLean (Adam MacLean)

Honored to contribute #mathonco cover art, created in #julialang w Jesse Kreger This posterior parameter rainbow shows us a path towards stopping immunosuppression in its tracks for better tumor outcomes. Paper here: aacrjournals.org/cancerimmunolr…

The SMB DEI Committee is launching a new summer series of webinars - please consider joining us!! Registration info and further details below 👇

SMB - Society for Mathematical Biology is celebrating diversity all summer long! just 6 days until the first Diversity in Math Bio seminar! hear from Dr. Stacey Smith? and Juliana Londono-Alvarez on Tuesday May 30 at 11:00 EDT / 17:00 CEST register to receive the Zoom info: tinyurl.com/SMB-Diversity-…

less than one week away from the 2nd set of Diversity in Math Bio talks from SMB - Society for Mathematical Biology ! hear from Dr. Alan Veliz-Cuba and Dr. Keisha Cook (Keisha Cook, Ph.D.) on Tuesday June 13 at 11:00 EDT / 17:00 CEST register to receive the Zoom info: tinyurl.com/SMB-Diversity-…

From being a Junior Chess Champion🏆 to becoming a Professor at Occidental College, math has always been a crucial part of Dr. Ron Buckmire’s life. For him, being a professor is about more than just teaching math. He strives to serve as a role model and advocate for all future

Congratulations to USC Norris member Dr. Evanthia Roussos Torres who recently was awarded R01 funding from the National Cancer Institute to investigate how targeting myeloid suppression enhances anti-tumor immunity in breast #cancer. #CancerResearch #breastcancer

New preprint out now! w Jesse Kreger Jazlyn Mooney, PhD & Darryl Shibata In which we show that stem cell variation leading to clonal hematopoiesis (CH) is likely present before birth. CH becomes pervasive as we age, this presents a sticky problem... biorxiv.org/content/10.110…

Gastrulation-stage heterogeneous Nipbl expr. foreshadows the development of birth defects This was a really fascinating study & great collab w Lander & Calof labs UC Irvine ...we discovered a key role for Nanog overexpression in mis-directing cell fates news.uci.edu/2024/03/21/uc-…

When do stem cell clonal dynamics begin? This was fun to write with Jesse Kreger for Mathoncoblog

This week in #MathOnco 293: - reinforcement learning - systems biology - treatment holidays - spatial patterns Art: Jesse Kreger, Adam MacLean (Nightcafe)

A new Neu --- a syngeneic model of spontaneously metastatic HER2‑positive breast cancer. this model offers us the ability to ask fascinating questions of the metastatic TME... watch this space for more to come. Fantastic collab w Evanthia Roussos Torres, MD, PhD lab link.springer.com/article/10.100…

A new Neu - a syngeneic model of spontaneously metastatic HER2‑positive breast cancer - Adam MacLean Evanthia Roussos Torres, MD, PhD Aaron G. Baugh Jesse Kreger Isaac Chan, MD, PhD Aaron G. Baugh Luciane T Kagohara 🇧🇷🧬👩🏻‍🔬👩🏻‍💻 Dr. Elizabeth Jaffee oncodaily.com/69736.html #Cancer #BreastCancer #OncoDaily #Oncology

Published now in Nat Comms... Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life nature.com/articles/s4146… Jesse Kreger Jazlyn Mooney, PhD

What is Cancer Systems Immunology and why is it needed to learn mechanisms driving immunotherapeutic responses in cancer? See how we are integrating experimental and clinical data with theory to accelerate the discovery of mechanisms of response to novel therapeutics!