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So excited to share our new paper out today in nature. We repurposed R2 retrotransposons to create STITCHR, a tool that can make diverse edits in mammalian genomes including scarless multi-kilobase scale insertions nature.com/articles/s4158…

Congratulations Kaiyi Jiang on a fantastic defense! So excited to see you move on as Assistant Professor Princeton University Omenn-Darling Bioengineering Institute, can't wait to see what comes out of your lab.

🧬 A new fungal #CRISPR? Fanzors are the first confirmed eukaryotic RNA-guided #DNA endonucleases. Jiang et al. discuss these promising tools for mammalian #GenomeEditing. #geneticengineering #biotechnology ➡️ doi.org/10.1002/1873-3… Kaiyi Jiang; Omar Abudayyeh; Jonathan Gootenberg

I've been waiting for the day I could make this video! Retrotransposons are reprogrammed for pretty efficient gene insertion up to 12.7kb in user-defined genomic targets. Small deletion + insertion possible too. Awesome work from Jonathan Gootenberg Omar Abudayyeh Chris Fell

🚨 New preprint 🚨 We introduce Generative Distribution Embeddings (GDEs) — a framework for learning representations of distributions, not just datapoints. GDEs enable multiscale modeling and come with elegant statistical theory and some miraculous geometric results! 🧵

New lab preprint! 🚀 Modeling complex data distributions is tough. We designed GDEs, a new framework that tackles this head-on! GDEs generalize across text, images & MANY bio apps (think virtual cells, spatial bio, viral genome tracking). Thread 👇

New preprint! GDEs came from our virtual cell work--turns out that framing as sets (e.g. cell types) and not individual points unlocks big performance boosts. Looking forward to seeing GDEs in many applications! Really fun building w/ Gokul + Nic Fishman. Read more from Nic👇

Only 1 in 20 drugs ever makes it to market—what if AI could flip that? At Harvard Medical School's AbuGoot Lab, Omar Abudayyeh & Jonathan Gootenberg are using machine learning to predict how cancer cells respond to drugs before trials even start. Presented by Rho, modern finance tools.

Could cancer vaccines become a software update for your body? At Harvard Medical School's AbuGoot Lab, Omar Abudayyeh & Jonathan Gootenberg are building a future where treatments are personalized and deployed in days—not months. Presented by Rho, financial tools for fast-moving teams.

📢 Introducing Biomni - the first general-purpose biomedical AI agent. Biomni is built on the first unified environment for biomedical agent with 150 tools, 59 databases, and 106 software packages and a generalist agent design with retrieval, planning, and code as action. This

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Earlier this year, I reached conviction that we'd see true agentic software engineers within 18mo, and I didn't want to miss out on the fun. Excited to share that I've joined the @openai Codex team to work on this! We're quickly growing the team in SF - hiring FS/product and