Ever wonder if your favorite protein is clustered? Excited to introduce a new reporter strategy called CluMPS that answers this question by amplifying small protein clusters, even endogenous ones. New preprint led by @confocalTom 1/n biorxiv.org/content/10.110…

Also, our lab is looking for postdoctoral fellows, graduate students and research technicians. Please apply via email if interested. theaugustinelab.org

Interested in understanding how and why IDRs matter for cellular function? Birthe B. Kragelund and I took a deep dive into this question and – with excellent feedback and critiques from colleagues & our amazing editor – put together our perspective on this: nature.com/articles/s4158…

Two talks from our lab today!! Xiaohang Cheng is presenting about focal adhesions and Maria Ullo is presenting about EGFR #cellbio2023

Last day of posters and talks from the lab. Maria Ullo will present her poster on EGFR spatiotemporal organization at board 490 and PhD student Nick Lea will give a talk in the spatial organization of metabolism and signaling minisymposium #cellbio2023

Writing or reviewing a manuscript? Watch out for these ten common statistical mistakes ⬇️ 6/n elifesciences.org/articles/48175…

🥉 Third place in our top 5 countdown is a PLOS Pathogens paper by Dr. Jibin Sadasivan and a team in the Eric Jan! Congratulations! 🥳 x.com/ScienceVancity…

Check out the 2nd SnapShot of the ribosome biogenesis series featuring the 60S ribosomal subunit! This was a great collaboration w Ed Hurt & Roland Beckmann. Read the SnapShot & watch the animation w narration here: sciencedirect.com/science/articl…

Defining the EM-signature of successful cell-transfection biorxiv.org/cgi/content/sh… #biorxiv_cellbio

AlphaFold2 and RoseTTAFold are limited to predicting the 3D structure of proteins. A new all-atom method models complete biomolecular assemblies, including proteins, nucleic acids, small molecules, metals, and covalent modifications. #NBThighlight science.org/doi/10.1126/sc…

Happy Golgi Day

The phrase ‘metastasis accounts for 90% of cancer deaths’ is one of the most widely used in cancer research, yet it is overly simplistic, imprecise, and it is difficult to find any primary analysis supporting the statement. | → rdcu.be/dLgsZ ← | 🧵(1/5)

#jvirology “Identification of the proteolytic signature in CVB3-infected cells” from Jan et al. Eric Jan The Overall Lab. doi.org/10.1128/jvi.00…

🚨 New from HHMI: Beautiful Biology 🚨 A visual journey into the microscopic world, showcasing biology’s hidden beauty. Discover stunning images from cutting-edge research paired with science-backed insights. Dive into the unseen: hhmi.org/beautifulbiolo… ✨

🌿 Welcome to HHMI’s Beautiful Biology! Explore hidden beauty in the biological world with these stunning images. From a fungus cross-section to the early stages of a flower, the natural world has never looked so fascinating! Explore more: hhmi.org/beautifulbiolo…

Out today in Molecular Cell Our review article highlights recent advances in ribonucleoprotein condensate biology, focusing on RNA-driven phase transitions. Efforts led by Gable Wadsworth and Sukanya Srinivasan. authors.elsevier.com/a/1jt7A_Oylrla…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living cells is out now PNASNews: pnas.org/doi/10.1073/pn…. MIT Biology MIT Science @HHMINews See quoted thread on the updated preprint for details: