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RIP 🙏

I feel seen

“In short, genetically defined impairments in oxidative metabolism may stimulate aerobic glycolysis in cancer, but, in general, aerobic glycolysis does not predict loss of oxidative metabolism.”

This thread is an archeological paradise

2020 has been terrible for many reasons, but there have been some really cool metabolism papers this year. In no particular order, here are my top 10 (because I couldn't get it down to 5). A thread!

For its potential to revolutionize fields like developmental biology and cancer research, spatially resolved transcriptomics is Nature Methods' Method of the Year. Senior VP R&D Michael Schnall-Levin explains how 10x Genomics is playing a key role. nature.com/articles/s4159…

If only I can explain what I study with such elegance as in this figure From review sciencedirect.com/science/articl… by Samantha Morris

QSER1 protects DNA methylation valleys from de novo methylation science.sciencemag.org/content/372/65…

It’s my pleasure to be the host 😊 Thank you for giving us a very interesting presentation and stimulating discussions! Excited for more research on the 3D genome, enhancer functions, and pluripotency

Spelling bee woes

“At UChicago, Szostak will lead a new interdisciplinary program called the Origins of Life Initiative, which will seek to understand the earliest processes governing the origin of life on Earth and elsewhere in the universe.” 😍😍

Stoked that our review is online now! Writing this article has definitely been a learning experience for me and I couldn’t have done it without the help of my mentor Dr. Danwei Huangfu and everyone in the lab. Couldn’t ask for a better Christmas gift :) authors.elsevier.com/a/1eIOA3QxxSjV…

Epigenome rewiring in human pluripotent stem cells dlvr.it/SFzMGD

And that’s a wrap! Attended my ever in-person conference✅ Listened to cool talks from 9 to 7 everyday✅ Gave a poster and learned about many more✅ Reunited with former lab members ✅ Thank you #ISSCR2022 for this amazing experience!

Happy to share a new preprint, Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions biorxiv.org/content/10.110…, led by Renhe Luo, and in collaboration with Michael Beer, and

Representing the Huangfu lab at #ISSCR2023 📌 Check our posters 477, 480 and 377 to learn more about our latest work on epigenetic regulation in hESCs using CRISPRa/i screens and other cool tools Dr. Danwei Huangfu Jielin Yan

I am really happy to finally share the preprint of our work unraveling a new class of regulatory regions distinct from enhancers that confer hESCs with the competence to rapidly activate the expression of lineage genes🧬 biorxiv.org/content/10.110… #stemcells #epigenetics #CRISPR

Honored to be part of this project that has taught me so much about enhancer biology, interdisciplinary collaboration, and conceptualization through multi-dimensional datasets!

Officially out in Nature Metabolism📖: our latest work showing changes how cells acquire amino acids during early development. Congratulations to Pavlina! rdcu.be/du2Z7 SKI_CellBio

Mice are not humans. We explore how distinct expression profiles of glucose transporters (GLUT1/GLUT2) in murine and human β cells can contribute to different blood glucose ranges in mice and humans. Congrats to Inbal Caspi & collaborators, and check out Inbal's mathematic model!