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Our preprint reporting the structure and mechanism of the natural product translation inhibitors paenilamicins is out…completely novel binding site on the ribosome! dlvr.it/T7CNnf…great collaboration with ⁦Suessmuth Lab⁩ ⁦Mankin_Vazquez_Lab⁩

Research by Ye et al. reveals that the human #tumor suppressor PDCD4 inhibits #protein translation initiation by blocking the 40S ribosome's mRNA entry channel during #stress. Read more: nature.com/articles/s4142… #Cancerresearch #Translationregulation #RibosomeInteractions #cells

Together with the amazing Beckmann Lab, we have uncovered that tigecycline not only blocks A-site tRNA binding but also directly binds to the PTC on the human 55S mitoribosome. nature.com/articles/s4146…

Protein synthesis in Bacillus subtilis: resolution of ribosomal stalls by ABCFs YdiF, YfmM, YfmR/Uup and YkpA/YbiT, EF-P loosing its modification but not its functionality, and a genetic interaction between EF-P and BipA! Out in Nucleic Acids Res academic.oup.com/nar/advance-ar…

Authors including Jingdong Cheng report cryo-EM structures revealing how antibiotic tigecycline can also target human mitoribosome. nature.com/articles/s4146…

bioRxiv: SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma dlvr.it/T9zQ95

ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site | Nucleic Acids Research | Oxford Academic academic.oup.com/nar/advance-ar…

First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

bioRxiv: The RNA helicase HrpA rescues collided ribosomes in E. coli dlvr.it/TD7XvQ

We’ve captured the splitting image of Slh1: our work on an enzyme that splits collided ribosomes in E. coli is out on bioRxiv! Huge thanks to the Beckmann Lab, Burroughs, and Aravind for a great collaboration. biorxiv.org/content/10.110…

Our latest work on structures of translation initiation complexes trapped by natural product inhibitors kasugamycin, edeine and GE81112 is out in the Biorxiv…biorxiv.org/content/10.110…

Paenilamicins represent a promising new class of antibiotics : MIN Faculty : University of Hamburg min.uni-hamburg.de/en/ueber-die-f…

It is always our great honor to work with the great Green lab. Green Lab meanwhile, great thanks to The EMBO Journal

LARP1 binds ribosomes and TOP mRNAs in repressed complexes Jingdong Cheng, Green Lab and coworkers find that direct binding in the mRNA channel of the 40S subunit is not required for LARP1-mediated TOP mRNA stabilization or translational repression embopress.org/doi/full/10.10…

Nice short/introductory review in all things ribosomes by pioneer Harry Noller in the special 50 years issue of Cell. The ribosome comes to life: Cell cell.com/cell/fulltext/…

Our latest study, in collaboration with the Hurt lab, Benjamin Lau , Fei Xavier Chen and Reinhard Lührmann, reveals how DHX35 and GPATCH1 work together to reject aberrant splicing substrates, ensuring splicing fidelity. #CryoEM #Splicing #Spliceosome nature.com/articles/s4142…

Jingdong Cheng's lab elucidates how DHX35 helicase and its cofactor GPATCH1 proofread an aberrant 5’ splice site in a catalytically activated spliceosome by unwinding the U2 RNA-branch site helix, ensuring splicing fidelity. 🔗nature.com/articles/s4142… FuDan University

In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs…academic.oup.com/nar/article/53…