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Too real...

I am very thankful for the fantastic post-docs that bring their diverse talents and backgrounds to our group! Nicole Marino, Shweta Karambelkar, Balint Bálint Csörgő Jingwen Guan, Yuping Li (Yuping Li), and Sukrit Silas (incl former: B. Rauch, S. Govindarajan)! #ucsfNPAW #NPAW2020

Scotland and Iceland #photos #photography #Scotland #Iceland

Delighted to share our latest preprint: the largest analysis assessing the contribution of rare genetic variants to the risk of depression, based on the exomes from 320,356 UK Biobank participants medrxiv.org/content/10.110…

Here, Jingwen Guan presents a new way to engineer phage genomes, using Cas13a + an Acr protein! We developed this because our favorite jumbo phage, phiKZ had no genetic tools. We are now using this to understand the jumbo phage secrets. short🧵biorxiv.org/content/10.110…

Thank everyone for your hard work and insightful suggestions! We hope this new technology can benefit the phage world as well as phage therapy in the future!

Love is Love.

Does JukA sense ejected proteins? In phage head, phiKZ genome is wrapped around a proteinaceous inner body (IB) structure. It is unclear if IB proteins are ejected with phiKZ genome. Via fluorescence tagging, Jingwen Guan showed that 4 IB proteins are ejected into host. 11/n

Introducing... "jumbo phage killer"! Check out our latest work led by the super-talented post-doc Yuping Li!