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@bdelloid Also see: academic.oup.com/nar/article/43… (circa 2015) by Aravind group and colleagues

Coming soon: A "cheatsheat" of some of the widespread anti-invader(e.g., antiviral) molecular immune processes and their sharing across the superkingdoms of Life. Each protein structure is a real rendering of an actual exemplar. The image is divide into three columns representing

Had a fantastic time engaging with Manu (PrakashLab) at the NIH. Inspiring conversations and insights.

🔍Apprehending the NAD+–ADPr-Dependent Systems in the Virus World ✍️by Iyer et al. 👉mdpi.com/1999-4915/14/9… #RNA #virology

Growing roles for the NlpC/p60 clade of the Papain-like fold in lipid biochemistry. Nice collaboration with Ethel (Ethel Bayer Santos) and Robson's (Robson F. de Souza) labs. Gianlucca Nicastro

The cytoplasm is not necessarily chemically uniform, says Delerue, Updegrove, & @Sylvia_Char. Surface of the developing spore inside the #Bacillus subtilis mother cell is acidic & needs a chaperone to activate MurG (lipid II synthase) pnas.org/doi/epub/10.10…

A chaperone assists peptidoglycan synthesis during sporulation Our new paper with the Kumaran Ramamurthi Vivek Anantharaman on a cellular nano-environment-specific chaperone that defines a novel clade of AAA+ ATPases is out. While SpoVK was recognized as an AAA+ ATPase in our earliest

Comet C/2023 A3 (Tsuchinshan-ATLAS) under city lights from Bethesda: a heavenly interloper from the Oort cloud

Phenotypic heterogeneity may be ACTIVELY generated (not just passively by stochastic gene expression) in a population of sporulating #Bacillus subtilis, says Updegrove et al. A new sporulation pathway with 2 proteins of previously unknown function... science.org/doi/epdf/10.11…

A really fun collaboration with Aravind group, Vivek Anantharaman (computational evolutionary analysis), H Shroff, J Chen (DNA-PAINT), H Cho (fancy statistics) L Jenkins (mass spec), & C Bewley (NMR to identify glycerol as the secreted signal), and several former postbacs.

Félix Ramos-León took on a ~50-yr-old mystery in #Staph aureus cell biology and came out on top! Check out his paper on how #Staphylococcus aureus chooses its cell division plane, how it forms clusters, and why all this matters during infection... nature.com/articles/s4156…

🦠➗OUT NOW - PcdA promotes division plane selection in #Staph by Kumaran Ramamurthi Félix Ramos-León @braf_phd Vivek Anantharaman Amany M. Missiakas Lab CambergLab Aravind group @NCIResearchCtr nature.com/articles/s4156…

From anti-invader immunity to the cytoskeleton: the tale of McrB proteins This work with Kumaran Ramamurthi Vivek Anantharaman shows how a protein involved in bacterial immunity gave rise to a novel lineage-specific cytoskeletal protein. The McrB proteins are AAA+ ATPases that typically

Extracellular Calcineurin-like phosphoesterases foster and signal altruistic behavior in bacteria This new work with Kumaran Ramamurthi Vivek Anantharaman and colleagues uncovers a new role for extracellular calcineurin-like phosphoesterases in bacteria. The calcineurin-like

New modulatory N-linked glycosyltransferase complex subunit, signaling and bone-development N-linked glycosylation is one protein modification that can be confidently inferred as being present in the Last Universal Common Ancestor of all life. The inferred ancestral version of