🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Xin Zhou, Dir of Data Visualization, shares how the St. Jude survivorship portal -- the first data portal for sharing, analyzing and visualizing pediatric cancer survivorship data -- may facilitate breakthroughs in pediatric cancer survivorship research. Learn more in Cancer Discovery.

Congratulations to Ching-Hon Pui, MD, for receiving the AACR-@StBalrdricks Foundation Award for Outstanding Achievement in Pediatric Cancer Research. Your pioneering research is lifesaving, and your commitment is inspiring. ow.ly/EzF250Ra17K #AACR24

Single-cell systems pharmacology identifies development-driven drug response and combination therapy in B cell acute lymphoblastic leukemia dlvr.it/T5QvYV

Big congrats, Dr. Pui! So well deserved!!!

Thanks so much, @NCIsysbio , for the wonderful tweetorial of our recent work and for the wonderful support to our #NCICSBC U01 grant with Jun Yang St. Jude Research (reporter.nih.gov/search/2JHO4aT…), which motivated us to extend the idea from T-ALL to B-ALL. Much appreciated!!

🚀 We're hiring! Join St. Jude as the Administrative Director for Computational Biology department. Support cutting-edge research, manage operations & sizable budgets, and enhance our mission to cure pediatric diseases. Apply now and make a difference! shorturl.at/C45fJ

Why is #ALL highly curable in #kids but carries a much worse prognosis in #adults?? Check out our new paper Journal of Clinical Oncology describing genomics of age-related differences in ALL drug sensitivity St. Jude Research MD Anderson Cancer Center UChicago Leukemia Program Nitin Jain

In case you are not satisfied with your scRNA-seq normalization and bulk RNA-seq deconvolution results, ReDeconv might be worth trying. Kudos to Songjian Lu in the lab who discovered the importance of transcriptome size and developed the tool!

.Jiyang Yu St. Jude Research introduce new methods for cell type deconvolution and scRNA-seq data normalisation. #BiotechNatureComms nature.com/articles/s4146…

St. Jude scientists leveraged findings about how cancer cells reduce the effectiveness of immunotherapy to suggest a combination treatment to reduce leukemia relapse. Read more: ow.ly/VhTj50V69eE

Now online in Cancer Discovery: GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR-T Cell Resistance via Macrophage Remodeling - by Jayadev Mavuluri, Yogesh Dhungana (Pronounced: Dhung-gä-nä),Jiyang Yu, Terrence Geiger, and colleagues doi.org/10.1158/2159-8… St. Jude Research

Beautiful work by an incredible St. Jude PhD student Yogesh Dhungana (Pronounced: Dhung-gä-nä) St. Jude Graduate School of Biomedical Sciences and JD, a staff scientist in Dr. Geiger’s lab. Yet another example of hidden driver analysis and perfect synergy of computational and experimental approaches!

Kudos to Jiyuan Yang, a postdoc in The Yu Lab, for his amazing transformation from plant biology to spatial & computational wizard—truly a #Transformer! Fantastic collaborations w Kaibo Liu and his former #ML star student Ziqian Zheng (UW–Madison) & Junmin Peng St. Jude Research.

🚀 Dive into spatial transcriptomics with Spotiphy! In this tweetorial, we'll walk through deconvolution, decomposition, and imputation of mouse cortex Visium data. Perfect for #singlecell & #SpatialTranscriptomics enthusiasts! 🧬🐭 #PythonTutorial

Out yesterday from the Peng, Liu, and Yu labs! Spotiphy (spot imager with pseudo-single-cell-resolution histology) transforms sequencing-based spatially resolved transcriptomics data into whole-transcriptome images with single-cell resolution. nature.com/articles/s4159…

Exciting that our Spotiphy paper was featured as this month’s cover story in Nat Methods. Thank you Nature Methods! Congrats to Jiyuan Yang, PhD The Yu Lab St. Jude Research and our Spotiphy Team!!

We’re excited to announce Hongbo Chi, PhD, as the new Chair of the St. Jude Department of Immunology. His leadership will advance our mission to find cures for catastrophic childhood diseases.

It's a lab signature tool for scRNA-seq clustering, network and hidden driver analysis we have been developing in the past 8+ years!!! Finally it's out. Feel free to try it out github.com/jyyulab/scMINER and check out our visualization portal: scminer.stjude.org.

From the May issue: GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR-T Cell Resistance via Macrophage Remodeling brnw.ch/21wSZir By Jayadev Mavuluri, Yogesh Dhungana (Pronounced: Dhung-gä-nä), Jiyang Yu, Terrence Geiger, and colleagues. St. Jude Research

Nice blog post by Qingfei Pan and Sarah August for thoughts behind our recently-published scMINER tool St. Jude Research The Yu Lab (nature.com/articles/s4146…): communities.springernature.com/posts/catching…