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Another amazing looking paper from the Jonathan Pritchard lab!

New approach to discovering the biology of GWAS signals “by combining quantitative estimates of gene-trait relationships from loss-of-function burden tests with gene-regulatory connections inferred from Perturb-seq experiments in relevant cell types.”

Thank you Jonathan for the elegant explanation of our recent work! We dove into how we can model the gene regulatory architecture of complex traits with 1) gene effects from LoF burden tests and 2) Perturb-seq. It’s been an incredibly exciting and thought-provoking journey!

Our paper, many years in the making, is out today! We use high dimensional imaging phenotypes to interpret the effects of genome-wide perturbations, & find some cool biology