🎉 A great result by the collaboration among Ballabio’s and Gennaro Napolitano's group and the two first co-authors NunziaP and Adrien Pasquier revealed the key role of #TFEB and #TFE3 in controlling the #GlucoseHomeostasis! More here: embopress.org/doi/full/10.15… #TigemPapers

AlphaMissense, a tool by DeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a new Science study. Learn more: scim.ag/49l

Thrilled to announce our latest exploration of CRISPR! By developing an advanced algorithm, we’ve analyzed 8 terabases of microbial data, leading to the discovery of over 200 novel CRISPR systems. Kudos to Han Altae-Tran and Soumya Kannan for their exceptional work! Details in the

An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predictions or parts of predicted structures do not agree with experimental data. @TerwillTom nature.com/articles/s4159…

CRISPR 2.0: a new wave of gene editors heads for clinical trials go.nature.com/41cl5vk

In two independent Science studies, researchers used time-resolved crystallography at an x-ray free electron laser to capture the process of #DNA repair from picoseconds to microseconds. Learn more ⬇️ 📄: scim.ag/57W 📄: scim.ag/57V

⏰WE ARE HIRING 3+y postdoctoral positions in the context of a major Fondazione AIRC per la ricerca sul cancro grant 🎉 we will pursue our studies on mitochondrial mechanotransduction in breast cancer metastasis, including new mouse models & new drugs in the pipeline Please RT and DM if you are interested

#AlphaMissense, a tool by Google DeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a Science study. Learn more: scim.ag/5iY

still one of the top christmas gifts i have ever received 🧬

DNA damage and transcription stress dlvr.it/T10QkW

👏👏👏👏👏👏👏👏👏👏👏👏👏

nature.com/articles/d4158…

Having a great time at our FOR2625 symposium in Berlin with great science of our FOR2625 members and amazing external speakers from around the world 👌😀

There is still time for abstract submission! Please, share! 😊

Congratulations to Sara for publication of her new paper🥳👏 We investigated effects of the lysosome enrichment approaches SPIONs and TMEM192 overexpression on the lysosomal proteome and combined both to achieve highly pure lysosomes. Check it out : pubs.acs.org/doi/10.1021/ac…

Paul Gissen is a great speaker and a wonderful advocate for rare disease. Lovely to hear him chatting away with Nicola Brunetti and JulienBaruteau in this episode on Liver Directed Gene Therapy.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have

Don’t try this at home, but Colossal Chief Science Officer, Dr. Beth Shapiro, breaks down the extremely complex process of making a dire wolf into a simple seven steps you’ll actually understand.