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Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control biorxiv.org/cgi/content/sh… #biorxiv_immuno

Catabolism of extracellular glutathione supplies amino acids to support tumor growth biorxiv.org/content/10.110… And a very exciting piece of work from @isaac_s_harris & team!

Excited to share the first research publication from our lab! Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking sciencedirect.com/science/articl…

🚨 Preprint alert! Our new work uncovering that glutathione (GSH) boosts tumor growth by supplying amino acids is now available at @bioRxiv! Check it out 👇🏼and follow along for the #tweetorial (1/10) biorxiv.org/content/10.110…

Have you ever wondered how mitochondrial and cytosolic pathways for de novo lipogenesis (DNL) interact? We did! Published Online today (cell.com/cell-metabolis…) and led by first-author Adam Rauckhorst, we traced 13C-labeled lactate/pyruvate, acetate, the ketone

New pre-print from the lab! We describe an alternative route for β-hydroxybutyrate metabolism that allows it to bypass the TCA cycle to support fatty acid synthesis in cancer cells. Check it out! 👇 biorxiv.org/content/10.110…

1/ Did you know? Glycans—complex sugar structures—decorate almost every protein processed by the ER/Golgi. These N-glycans coat our cells, playing critical roles in cell interactions and immune processes. 🍬 Curious about how they vary? Let’s dive in!

Today in Cell we report a new pathway of ketone metabolism. This BHB shunt generates an orphan family of anorexigenic ketone metabolites that are chemical cousins of exercise-inducible Lac-Phe. Congratulations María D. Moya-Garzon Sarafan ChEM-H cell.com/cell/fulltext/…

I've been on a Twitter moratorium for the last week given the.. news, but I'm happy to announce a new story from our group Nature Immunology describing a metabolic sensitivity of exhausted T cells to lactic acid in tumors! 1/ nature.com/articles/s4159…

Happy to announce our collaboration with Kaechlab (Sue Kaech) on metabolic features of exhausted T cells is now out in Science Magazine. TL;DR they can't use acetate to fuel their function. Great work by Shixin Ma and Mike Dahabieh. science.org/doi/10.1126/sc…

Thrilled to share our latest study in Science Immunology! We reveal the critical role of Srebf2-dependent cholesterol metabolism in the clonal expansion of insulin-sensitizing ST2hi VAT Treg subsets, and how obesity disrupts this process. science.org/doi/10.1126/sc…

1/ 🌟 Excited to share our latest review in Annual Review of Pathology: Mechanisms of Disease! Annual Reviews 🌟 Obesity isn’t just a metabolic disorder—it’s a fundamentally altered immunological state. Read it here: annualreviews.org/content/journa…

Excited to share our work from the J. Andrew Pospisilik lab, now in #NatureCancer! #Epigenetic heterogeneity via Trim28, arising early in #development, shapes long-term #cancer risk. Check it out: nature.com/articles/s4301…