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Our HiDRO paper is now published in nature nature.com/articles/s4158… Since the preprint, we made a few key additions worth checking out. Thanks to reviewers for their helpful suggestions! Original tweetorial posted below:

Put this on your "to read" list! Impressive feat led by Daniel S. Park to screen the druggable genome for regulators of chromatin organization

I'm really excited to present work from Ophir Shalem’s group with my outstanding co-first author Yevgeniy Serebrenik Yevgeniy Serebrenik to tag and manipulate proteins at scale, which we use to study the #proteome and #proteostasis biorxiv.org/content/10.110…

The Rosin Lab is still hiring! We are looking for motivated postbacs and postdocs (fully funded!) to study chromosome dynamics in the germline and soma in insect and mouse models. Our newest recruit arrived in June and she is ready to meet her new labmates ❤️

Excited to announce that registration is now open for the Fourth Annual Meeting on Advances in Nuclear Topology and 3D Chromatin Architecture in Cancer. As always we have a fantastic lineup of speakers!

Excited to see our latest collaboration with @DrinnenbergLab and Leonid Mirny lab looking at interphase genome organization in Bombyx online now!

How is chromatin binding of the Type 2 nuclear receptor (T2NR) network regulated? New work out now on bioRxiv led by Liza Dahal w/ Thomas Graham Gina Dailey Alec Heckert Xavier Darzacq biorxiv.org/content/10.110…

A major limitation for #genetherapy is delivering large cargo with #AAV. We know that AAV vector DNA concatenates into large episomes in the nucleus, but how does this happen? Led by Anna Maurer we built a system to watch AAV vector genomes in live cells 1/ 🧵

Excited to share my Ph.D. work in Carl June lab showing uninhibited CD28 co-stimulation via CTLA4 disruption invigorates dysfunctional CART cells doi.org/10.1016/j.immu…

My brilliant, creative, unstoppable friend did very cool work toward even more powerful CART cell therapies:

So this happened while I was vacationing. Jack and I at the Tjian + Darzacq Group lab combined SM imaging with domain chopping (à la classical biochemistry) to determine which bits of p300 make it bind to chromatin in living cells. Turns out it's all about TF binding.

New study on #transcription regulation in human #placenta development - we find that the transcription factor #TFEB is required for the differentiation of a fusing cell type in the placenta (syncytiotrophoblasts) by controlling cell-cell fusion! biorxiv.org/content/10.110… 🧵

Thank you Scientia for highlighting our work in this outreach article! Carl June #CARTcelltherapy

Seeking someone looking for a two-year postbac position to get my group up and running at Yale University! We will be utilizing chromatin tracing and other multiplexed imaging approaches to study the relationship between 3D genome organization and epigenetic memory in embryos!

Phase separation

The first Rosin lab paper it out now in PLOS Genetics! Feat. postbacs Clio Hockens and Tricia Wang Tricia Wang and wrapping up my work with The Lei Team Chr. seg. during spermatogenesis occurs through a center-kinetic mechanism in holocentric moths rb.gy/ts9u64

#Placenta researchers - Are you a user of #BeWo cells? They’re a great model for cell-cell fusion, but have been a pain to transfect and manipulate genetically. We optimized and wrote a new easy-to-use protocol for #CRISPR editing in BeWo cells using RNPs! authors.elsevier.com/a/1jPaZ_3GhD8Y…

I am super excited to be running the Cal Women in Imaging Bootcamp again this year! If you missed us last time, sign up now - it's such a fun way to build community at the beginning of grad school and learn more about microscopes and careers along the way! 🔬👩‍🔬🌈 Link below 👇

We were certainly surprised to find that in human #placental cells the TF #TFEB does NOT control #lysosome gene expr. but instead regulates the expr. of Syncytins to control cell-cell fusion! Excited to see my work now (officially) published Genes & Development 👉m.genesdev.cshlp.org/content/early/…

Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab! doi.org/10.1038/s41592… 1/11