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Since my Harvard lab closed yesterday, I've been reading and interpreting this week's published papers on #COVID19. What follows is a thread of information, my interpretation, links to sources & predictions. Let's start with what you need to know... #coronavirus #COVIDー19

Sten Linnarsson will collect long sleeve single use lab coats and face masks at KI-BM C6 tomorrow (Sat 21.3.) 8:30am for KS ER who have run out. Please donate!

With widespread adoption of single-cell-omics technologies, developmental biologists are increasingly relying on the use of “gene expression trajectories” to study cell differentiation. What is the difference between a trajectory and a lineage? (1/4)

Very happy to see our work out in Science Magazine science.sciencemag.org/content/370/65… . This was a large effort by an amazing team J. Chell Pierre Le Merre Yicheng Wu Margherita Zamboni,J. Bergenstrahle,M. Stenudd,E. Sopova,Joakim Lundeberg,O. Shupliakov Marie Carlén and Jonas Frisén Thread 1/

Method of the Year 2020 is...spatially resolved transcriptomics! nature.com/collections/df… Read about why we selected this topic this year in our Editorial. nature.com/articles/s4159…

Finally out! We sequenced human single cells with PacBio Great collaborative effort by Adam Ameur Jakob Michaelsson @Jeff_Mold @samplix biorxiv.org/content/10.110…

So excited to share our preprint, demonstrating the use of long-read technology to analyze genomes of single human cells! The result of heavy development work by Joanna Hård @Jeff_Mold Jakob Michaelsson NGI Sweden SciLifeLab @samplix and others.🧵👇 biorxiv.org/cgi/content/sh…

Very excited to share our #preprint on TREX and Space-TREX in the mouse brain! Huge thanks to Leonie, Ludvig Larsson, Marcel Martin, Jakub Westholm, Gioele La Manno, Joakim Lundeberg and Jonas Frisén! Out now on bioRxiv Neuroscience 👉👉👉 biorxiv.org/content/10.110…

Very exciting work led by @Jeff_Mold and team demonstrating a new perspective on clonal dynamics Marty Weissman, Jakob Michaelsson, Carl-Johan Eriksson, Michael Ratz, Michael Hagemann-Jensen, Joakim Lundeberg, Leonie, Jonas Frisén

Clonal memories are an emerging revolution in understanding biology. It's been simmering for a while. Clonal biology is about to explode.

Single cell transcriptomics meets high-throughput lineage cell tracing with genetic barcodes! So happy to see our long journey out in Nature Neuroscience. It wouldn’t have happened without Michael Ratz, Marcel Martin (@[email protected]) Jonas Frisén and many more. Thanks to all!!

Come join us in Portugal in late May! We are running the third edition of CPANG. Learning to use pangenome methods in a hands-on way. In previous courses students worked at the cutting edge of the effort to transform the theoretical foundation of bioinformatics and compbio

Looking for someone to work on pangenome genotyping and imputation. Research consulting, competitive pay, worldwide, with preference for someone with systems (rust or C/C++) experience and interest in biology. Reach out if interested!

Are you, like us, wondering WHERE’S that CLONE? On behalf of the ‘Spatial VDJ’ team, here's full-length BCR and TCR mapping in human tissue using spatial transcriptomics (Visium). biorxiv.org/content/10.110… Kim Thrane Qirong Lin @Jeff_Mold Jonas Frisén Joakim Lundeberg thread 1/n

Here we unlock the power of PacBio long-reads further by calling SNVs, SVs and repeats in single cells

Great to see our single-cell long-read WGS work featured in The Scientist! Related preprint here: biorxiv.org/content/10.110… the-scientist.com/news-opinion/f…

Thrilled to see our paper out today where we use long-read whole-genome sequencing to study SNVs, structural variation and repeats in single cells nature.com/articles/s4146… Many thanks to everyone involved Adam Ameur, @Jeff_Mold, Jakob Michaelsson, NGI Sweden, SciLifeLab

Physical implementation of the UMAP algorithm.

Finally out! I am happy to have contributed to a small part of this important study demonstrating that gene expression is clonally inherited. Congratulations to @Jeff_Mold Marty Weissman Jakob Michaelsson and the rest of the team

🎥 We've interviewed Joanna Hård, CEO of Amun AI, a startup from KTH Royal Institute of Technology, who shares insights on their Hypha platform and the synergy with AI4Life: ai4life.eurobioimaging.eu/interview-amun…