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New CDN binding domain!

🧬 Big Pharma's antibiotic problem: A successful drug + FDA approval = $776M loss Here's how that happens 🧵

Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 science.org/doi/10.1126/sc…

Apply now, spread the word: three (3) fully funded Helmholtz research groups (assistant prof level) with attractive packages. Topics: RNA-based medicine, microbial RNA, and RNA-based infection research incl. RNA technologies. Great environment for young people. Come and join us.

📢Excited to introduce NanoCas -our new mini CRISPR system that can reach tissues previously out of reach! By shrinking CRISPR to 1/3 its normal size, we can now edit genes in muscle, heart & brain that were difficult to access before. Summary & link to paper:

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

Check it out! Favorite model organism? see what gene(s) you should work on. Favorite gene(s)? See what model organism you should use!

The lab is now up and running at New England Biolabs New England Biolabs! I'm looking for a postdoc to study phage defence systems. If you'd like the academic freedom to publish but the resources of industry, then take a look 🤓😃 neb.wd5.myworkdayjobs.com/en-US/NEB_Care…

In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ Rachel Silverstein CGM at MGH @MGH_RI MassGeneral News Harvard Medical School nature.com/articles/s4158…

Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…

How do bacterial extracellular Contractile Injection Systems bind target cells? A remarkable diversity of receptor binding domains biorxiv.org/content/10.110… #biorxiv_micrbio