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“Evolution of a minimal cell” in nature: nature.com/articles/s4158… Led by R with Brent Lehmkuhl at IU Biology J. Craig Venter Institute collaborators: Lijie Sun, Daniela Bittencourt, Kim Wise, John Glass Along with @dschoolmaster, and Mike Lynch Biodesign Institute at Arizona State University

The Salk Cell Cycle Meeting will start in just 10 days (July 24th) and the list of all speakers, including short talks, is now available. salk.edu/events/science… If you can't be there, registration for virtual attendance is still possible! #CellCycle2023

PDRA opportunity in our group UCL Chemistry to develop & characterise ribozymes that harness primordial chemistries. 28 months, funded by BBSRC & Royal Society; org chem or mol bio background. Apply by 7th August: tinyurl.com/4bhhf2v2

UK association with #HorizonEurope is finally confirmed! 🎉This agreement is thanks to the hard work of many people working to show the value of international collaboration during negotiations 🇬🇧🇪🇺

Excited to see our work on how #mitochondrialDNA copy number is coupled to #cellsize finally out. Thanks to Anika, Francesco Padovani and the whole team AlissaF Felix Thoma Osman S Borutecene ! rdcu.be/dlAak

New paper from my group out in x.com/natBME. Outstanding work by Ben Porebski and great collaboration with x.com/AstraZeneca. We describe a new high-throughput strategy for biomolecular discovery, which we call deep screening.

Looking for an outstanding PhD? Check out our PhD program The Francis Crick Institute Many great labs and projects available. Excellent training including transferable, out of the lab skills. If you are interested in the interplay between cell division and differentiation,we are the lab for you!

Excited to co-feature in Molecular Cell with 4 studies Gabriel Neurohr Adrian Saurin @Alexis_Barr Tony Ly and Simak Ali labs on CDK inhibitor sensitivity – for anti-cancer efficacy bigger is better! Excellent preview on all 4 studies by Kurt Schmoller cell.com/molecular-cell…

New paper out from my group pnas.org/doi/10.1073/pn…. CryoEM structure of the triplet polymerase ribozyme apoenzyme, with improved resolution from biorxiv.org/content/10.110…. Great collaboration with Ewan McRae and Ebbe Sloth Andersen

The latest pre-print from the lab is out, from the amazing @NitinKapadia27! Check out how he developed a new CDK activity sensor, uncovered the spatial dynamics of CDK activation at mitosis and probed the impact of this on the bistability of CDK activity in vivo!

We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. tinyurl.com/4a6yeuke. 1/10

There's been amazing coverage of our new paper nature nature.com/articles/s4158… but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...

#Cellsize is important for many cellular processes, including biosynthesis, organelle homeostasis and development. If you need an overview of how cell size is controlled, and how it affects cell function, we have you covered: doi.org/10.1152/physre… Yagya Chadha Arohi Khurana

We’re presenting AlphaProteo: an AI system for designing novel proteins that bind more successfully to target molecules. 🧬 It could help scientists better understand how biological systems function, save time in research, advance drug design and more. 🧵 dpmd.ai/3XuMqbX

Great collaboration with the Short Linear Motif team on defining short linear motifs required for cell fitness using base editor screens. Hundreds of novel functional SLiMs to explore! A proteome-wide dependency map of protein interaction motifs biorxiv.org/content/10.110…

We’re hiring! We have Wellcome-funded postdoc positions to join my group. The project will build on recent work on transcriptional cell size scaling (Swaffer et al. Cell 2023) to ask how gene expression, RNA metabolism and cell signalling are all coordinated with cell size (1/3)

Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d428… Check out the thread for an overview of the 9 #flywire papers published today

Want to explore how your protein of interest interacts with loads of other proteins using AlphaFold3 but don't have time to analyse hundreds of predictions? I wrote a Python script that might help streamline the process! Check it out here: github.com/sw249/Process-…

New preprint from our lab! 🎉 A phosphoproteomic adventure into how different phosphatases counteract CDK activity and how this can help to order substrate phosphorylation during the cell cycle. Find out more from first author, and my PhD lab partner in crime Theresa Zeisner