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the new york times came out with a great essay on universal antivenoms yesterday, discussing a recent Cell paper so i decided to tack on another 1,200 words to my existing antivenom essay (also released yesterday), examining the paper, its implications, and the obvious question:

In March last year, at the age of 35, I was diagnosed with advanced stage III rectal cancer with a metastasis in my liver. This was a shock: I had no family history, and none of the doctors suspected it. In fact, I'd had a negative occult blood test when I went to ER with severe

TIL pasteurization was initially developed for wine. From an interesting history of milk pasteurization in the US by Phoebe Arslanagić-Little worksinprogress.news/p/making-ameri…

This is a remarkable feat on so many levels. *Massive* congrats to Kiran Musunuru (former Circulation: Genomic and Precision Medicine EiC & Sek Kathiresan MD lab co-alum) Sarah Grandinette Rebecca Ahrens-Nicklas & team! nejm.org/doi/full/10.10… NEJM (coverage nytimes.com/2025/05/15/hea… The New York Times by Gina Kolata)

Regeneron to buy bankrupt genetic testing firm 23andMe for $256 million reuters.com/business/healt…

Interesting perspective relevant to the question: how valuable is one person's genetic information? The 23andMe sale price suggests a very precise number: $17 (obviously a tongue-in-cheek calculation given huge caveats and assumptions, but still)

Clues are emerging about the ghostly clan that settled eastern Asia and left a genetic legacy in people today go.nature.com/3ZlC1Qk

A set of non-coding genetic variants -- mutations in RNA genes-- cause neurodevelopmental disorders by disrupting alternative splicing across the genome nature.com/articles/s4158…

We've known how to provide ourselves w/ freshater for centuries--and w/ good clean water, even in the most crowded and dirty cities, since World War I. Yet we don't. Welcome to the world's most immediate--and most infuriating--environmental crisis. (By me) thenewatlantis.com/publications/h…

European sperm donor conceived at least 67 children from 46 families born between 2008 and 2015. Turns out he has a p53 mutation--> Li-Fraumeni cancer syndrome. Now 10 of children have cancer (brain tumor, lymphoma) and 13 others have the mutation. cnn.com/2025/05/27/hea…

As we all age, we accumulate mtDNA mutations, but what underlies this hockey stick pattern? See our new pre-print: we treat mtDNA SNV burden as a "trait" and use GWAS to uncover the mechanism in blood. Led by newly minted MD-PhD Rahul Gupta w/ NealeLab /labneale.bsky.social. shorturl.at/IqYY8

Interesting GWAS on accumulation of aging-related mitochondrial mutations biorxiv.org/content/10.110…

The micropipette—that ubiquitous tool found in laboratories around the world—was invented by a 32-year-old German postdoc in 1957 after a particularly productive two-day tantrum. That first device, made by Heinrich Schnitger, had “all the essential features of the modern

"Longevity Is Now a Factor When Picking an Embryo for IVF" Seems there's a nice niche for "consumer" genetic testing among couples doing IVF -- that's one of a handful of times in a person's life when they *really* care about their own genetics. wsj.com/health/embryo-…

Interesting analysis of 'human knockouts' in a south Asian population "Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity" medrxiv.org/content/10.110…

The time of day that immunotherapy is given seems to really, really matter. Why? note: a recent randomized study (quote given blow) presented at a major cancer conference found that giving immunotherapy in the morning instead of the evening led to a 2x higher survival rate.

Endometriosis is an incredibly interesting disease 5k words, 23 minutes reading time covering one of the strangest conditions ive ever heard about link: owlposting.com/p/endometriosi… very grateful to Shilpa Pothapragada for initial inspiration for this piece + reviewing it!!

Today, we are thrilled to announce that Verve Therapeutics has entered into a definitive agreement to be acquired by Eli Lilly and Company From 2018 to 2025, Verve moved a new concept (a one-dose future for the treatment of atherosclerotic cardiovascular disease) and a new medical technology (in

People started talking seriously about sequencing every newborn about 16 years ago. Here it is (maybe). telegraph.co.uk/news/2025/06/2…

In my most recent post, I dive deep on ctDNA testing and why it stands to profoundly change oncology. This is an area where my own thinking has evolved recently.