John Laffey (@johnglaffey) 's Twitter Profile
John Laffey

@johnglaffey

ICU doctor and Anesthesiologist/Researcher in ARDS and Sepsis/Proud Dad/Views my own

ID: 1205562656872189953

calendar_today13-12-2019 18:58:49

1,1K Tweet

1,1K Followers

314 Following

Intensive Care Medicine Experimental (ICMx) (@icmexperimental) 's Twitter Profile Photo

💊TCD-ABx in vitro: antibiotics in dialysis solutions help achieve desired plasma levels with both 'up-' or 'down-dialysis' towards the unbound target concentration. ✅An elegant life hack for antibiotic therapy during CVVHD? 🔓t.ly/b-MTy #FOAMed #CriticalCare

💊TCD-ABx in vitro: antibiotics in dialysis solutions help achieve desired plasma levels with both 'up-' or 'down-dialysis' towards the unbound target concentration. 
✅An elegant life hack for antibiotic therapy during CVVHD?
🔓t.ly/b-MTy
#FOAMed #CriticalCare
Intensive Care Medicine (@youricm) 's Twitter Profile Photo

◾️In memory of Prof L Gattinoni, towering figure in ICM, profoundly shaping understanding of #ARDS & #ECMO. The “father" of prone position revolutionized MV with a pioneering "baby lung” concept. His legacy will guide/inspire for generations to come. 🔗esicm.org/obituary-lucia…

◾️In memory of Prof L Gattinoni, towering figure in ICM, profoundly shaping understanding of #ARDS & #ECMO. The “father" of prone position revolutionized MV with a pioneering "baby lung” concept. His legacy will guide/inspire for generations to come.
🔗esicm.org/obituary-lucia…
Intensive Care Medicine Experimental (ICMx) (@icmexperimental) 's Twitter Profile Photo

🫀 transplantation, open‑lung vent in CPB, postop 🫁 damage. 🐑 model ✔️ OPENVENT Vt 3 mL/kg , PEEP 8 ✔️ NOVENT group no ventilation ✅ OPENVENT: ⬇️ histological🫁 damage ⬇️shunt ⬇️ DP ⬇️ neutrophil and macrophage infiltrations 🔓t.ly/BWbK1

🫀 transplantation, open‑lung vent in CPB, postop 🫁 damage. 🐑 model
✔️ OPENVENT Vt 3 mL/kg , PEEP 8 
✔️ NOVENT group no ventilation 
✅ OPENVENT:
⬇️ histological🫁 damage
⬇️shunt
⬇️ DP
⬇️ neutrophil and macrophage infiltrations
🔓t.ly/BWbK1
Intensive Care Medicine Experimental (ICMx) (@icmexperimental) 's Twitter Profile Photo

📃HyperO2-induced ⬆️ in 🧠 tissue pO2 (PbtO2) ✔️Circulating models 🔮 a ⬇️ PO2 ✔️Hb transition relaxed (R) to tense (T) state, driven by deO2 ➡️ pO2 diff. across 🧠 capillaries. ✅ Hb R to T ➡️ for ⬆️ PbtO2 lvls in 🧠 tissue during hyperO2. 🔓 t.ly/NhIIb #FOAMed

📃HyperO2-induced ⬆️ in 🧠 tissue pO2 (PbtO2) ✔️Circulating models 🔮 a  ⬇️ PO2
✔️Hb transition relaxed (R) to tense (T) state, driven by deO2 ➡️ pO2 diff. across 🧠 capillaries.
✅ Hb R to T ➡️ for  ⬆️ PbtO2 lvls in 🧠 tissue during hyperO2. 
🔓 t.ly/NhIIb
#FOAMed
Intensive Care Medicine Experimental (ICMx) (@icmexperimental) 's Twitter Profile Photo

Mitochondrial metabolic profiles in DKA ⬇️ cellular O2 consumption vs healthy controls. ✅O2 consumption ⬆️ in cells with thiamine or CoQ10 treatment ✅ Thiamine and CoQ10 could potentially have therapeutic benefits in DKA. #FOAMed #CriticalCare 🔓 t.ly/xDwm1

Mitochondrial metabolic profiles in DKA ⬇️ cellular O2 consumption vs healthy controls.
✅O2 consumption ⬆️ in cells with thiamine or CoQ10 treatment
✅ Thiamine and CoQ10 could potentially have therapeutic benefits in DKA.
#FOAMed #CriticalCare 
🔓 t.ly/xDwm1
Intensive Care Medicine Experimental (ICMx) (@icmexperimental) 's Twitter Profile Photo

Renal venous flow patterns in sepsis ✅Proximal (PRVF) and intrarenal venous flow (IRVF) not entirely congruent ✅PRVF ➕IRVF: ⬆️ predictive ability for 28-day renal function prognosis. ✅Early improvement in renal venous congestion is crucial 🔓 t.ly/zkOAW #FOAMed

Renal venous flow patterns in sepsis
✅Proximal (PRVF) and intrarenal venous flow (IRVF) not entirely congruent
✅PRVF ➕IRVF: ⬆️ predictive ability for 28-day renal function prognosis.
✅Early improvement in renal venous congestion is crucial
🔓 t.ly/zkOAW
#FOAMed
Intensive Care Medicine Experimental (ICMx) (@icmexperimental) 's Twitter Profile Photo

Effects of FCV using negative end-expiratory pressures (NEEP), on 🧠 hemodynamics in a 🐖 model of intracranial hypertension. ✅ FCV➕ NEEP appears to be safe ✅ additional tool for severe intracranial pressure episodes. 🔓t.ly/hBF7q #FOAMed #CriticalCare

Effects of FCV using negative end-expiratory pressures (NEEP), on 🧠 hemodynamics in a  🐖 model of intracranial hypertension. 
✅ FCV➕ NEEP appears to be safe 
✅ additional tool for severe intracranial pressure episodes.
🔓t.ly/hBF7q
#FOAMed #CriticalCare
Prof Karen English (@kenglishlab) 's Twitter Profile Photo

Cell & Gene Therapy Researchers in Ireland- Please submit your abstracts by Friday 10th January ⬇️ please RT and share with your colleagues

Vincenzo Russotto (@russottovin) 's Twitter Profile Photo

Exactly 1 yr ago we launched the STARGATEstudy. With new friends and connections, 8260 enrolled patients from 37 different countries worldwide🌎, we are grateful to all involved people for this year! 🎉

Exactly 1 yr ago we launched the <a href="/stargate_study/">STARGATEstudy</a>. With new friends and connections, 8260 enrolled patients from 37 different countries worldwide🌎, we are grateful to all involved people for this year! 🎉