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In the Orli Bahcall study, Franzén, Lindvall et al. (SciLifeLab and AstraZeneca) profile human IPF and (resolving) bleomycin-induced lung fibrosis in mice and focus on alveolar regenerative niche! (Love their abbreviation for Abberant Basaloid cell niche = AbBa 😉🇸🇪)

AbBa-Niche 😂😂😂 Naftali Kaminski

Michelle, you did a phenomenal job putting this conference together! AASOG is fantastic! And so much fun!!!

Die Else Kröner-Fresenius-Stiftung vergibt an sechs besonders begabte junge Ärztinnen und Ärzte die Else Kröner Memorialstipendien in Höhe von je 250.000 Euro. Herzlichen Glückwunsch! 🥳 Niklas Grassl , Bernd Heinrich, DietrichLab u. a. ➡️ ekfs.de/aktuelles/pres…

...and so it has begun! #ICLAF2024 Kicked-off by Argyris Tzouvelekis Thanks for organizing! Looking forward to an amazing conference!

Thanks Killian Hurley for visiting us BREATH Hannover! Amazing and inspiring talk, very cool data!!

On #HolocaustMemorialDay I recite my parents, #Holocaust survivors & child refugees, words: if you find yourself among the powerful one day - support the powerless, dispossessed, dehumanized - because we were once like them #NeverAgainForAnyone #יוםהשואה

Finally out as reprint!!! "Alveolar epithelial cell plasticity & injury memory in human pulmonary fibrosis". Glad to share the results of our single cell nuc-seq & ATAC-seq analyses of human IPF & PCLS before peer review - see the key findings in 🧵👇🏽 biorxiv.org/content/10.110…

1/n Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features. #ATi biorxiv.org/content/10.110…

2/n Using PAGA we define distinct trajectories among ATII, ATI, Aberrant basaloid cells & ATi cells that allow identifying specific markers for intermediate states & then validate and localize the presence of ATi populations in human IPF tissue #CTSE biorxiv.org/content/10.110…

3/n To understand emergence of aberrant basaloid cells in human PCLS we did time course analysis. Untreated PCLS -> ⬆️ alveolar epithelial diversity and proliferation suggesting FC treated PCLS -> ⬇️ proliferation & disease like aberrant basaloid cells biorxiv.org/content/10.110…

4/n 10x Genomics Multiome analysis allowed us to establish Aberrant Basaloid Cells as a distinct lung cell population. It is different from all other lung cells and characterized by ⬆️⬆️ AP1 accessibility reminiscent of Injury memory retention #Multiome biorxiv.org/content/biorxi…

6/n Deeply grateful to all contributors; Current or former #KaminskiLab members; generous collaborators: Takis, Ivan, Melanie, Jun, the FORMIDABLE KU Leuven team - Wim and Bart; and special 👏🏽👏🏽 to #SuperDuo : Schupp & Adams‼️ Fin. #SchuppAndAdams biorxiv.org/content/biorxi…

The Unagi paper is FINALLY out! We present the first application. of a novel AI tool to human pulmonary fibrosis snRNAseq data to identify cellular trajectories & reversak perturbations with proteomics & PCLS validations!! See 🧵 👇🏼 and paper here nature.com/articles/s4155…

🙏🏼👏🏼🙏🏼 Drs Zheng, Schupp, Adams, Clair, Justet, Ahangari, Yan, Hansen, Carlon, Cortesi, Vermant, Vos, De Sadeleer, Rosas, Pineda, Sembrat, Königshoff, McDonough,Vanaudenaerde, Wuyts & Ding for this amazing #AI2CureIPF collaboration!! nature.com/articles/s4155… and 🧵below 👇🏼

🚨 New in Nature Biomedical Engineering 🚨 We built virtual cells and disease models with deep generative AI—letting you simulate disease progression and test drugs in silico. Say hello to UNAGI 🧠🧬💊 @Kaminskimed Yuuuuuuuuuuuumin 🔗 nature.com/articles/s4155… #VirtualCell #AI4CureIPF