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It was a team effort! Aaron J. Scott MD Hagen Kennecke Van Morris, MD Manju George MVSc PhD Rectal Cancer Survivor Jonathan Loree Josh Smith, MD, PhD, FACS Dr. jordan berlin May Cho lisa kachnic

We have data now to personalize #rectalcancer treatment. Based on tumor factors and patient preferences. Gone are the days where most patients are treated the same way. These ⁦ASCO⁩ guidelines should help! ascopubs.org/doi/10.1200/JC…

🔥of the press Neoadjuvant nivolumab and relatlimab in locally advanced MMR-deficient colon cancer: a phase 2 trial Nature Medicine 👇doi.org/10.1038/s41591… ESMO - Eur. Oncology #ESMOAmbassadors #ESMO24

Vitamin D with CTx + bevacizumab in previously untreated mCRC #ESMO24 🔎SOLARIS (Alliance A021703) 👉ORR 51 vs 44% 👉mPFS 11.8 vs 10.3 mo, benefit for left-sided tumors? 👉mOS 25.6 vs 27 mo 👉AE ≥3 no difference 🧐🚫trial, no benefit for Vit D.. ESMO - Eur. Oncology #ESMOAmbassadors

#ESMO24 ESMO - Eur. Oncology CABINET - ph3 cabozantinib vs placebo in pre-treated advanced #Neuroendocrine NETs Alliance for Clinical Trials in Oncology NEJM Jennifer Chan 📌results presented by BICR for epNET and pNET ➡️ORR 5% vs 0 in epNET, 19% vs 0 in pNET ➡️PFS HR 0.38 in epNET, HR 0.23 in pNET OncoAlert OncologyEducation

NEO outcomes min 3 yr f/up presented at #ESMO2024 ! Neoadj FOLFOX/CAPOX + TES great for organ preserv’n in early rectal cancer: -LR 7.1% and 100% OS at 3 yr -LARS score unchanged from baseline -RT still an option for recurrence or 2nd pelvic CA Hagen Kennecke CCTG

Joint #CommNETs & NANETS guidance document on treatment informing features in NETs. Supplements loaded with comprehensive reviews of data for each biomarker (highlights where we need to generate data!) and patient education document co-developed with CNETS NeuroEndocrine Cancer Australia

‼️What guidelines are needed in #NETs care? @nanets1 needs your input!🫵🏻 Stop by guidelines board at #NANETS24 to leave your suggestions! By the registration desk. Or add in comments 👇🏻 & I’ll add to the board 🦓❓What about peritoneal carcinomatosis? Small PNETs? DIPNECH?

Nice to see CM8HW in press! NEJM 📌 n=303 centrally confirmed dMMR mCRC 1L ➡️ 2y PFS 72% nivo-ipi vs 14% chemo 🌟 Per earlier BMS release, combo is superior to nivo arm but awaiting data - in whom? by how much? toxicity diff? ❓How do we identify pts w/dMMR mCRC who may still

Recently published: #ClonalHematopoiesis of Indeterminate Potential (CHIP) & Its Association with Treatment Outcomes & Adverse Events in Patients with Solid Tumours. doi.org/10.1158/2767-9… Jonathan Loree Jp Solar Vasconcelos @rob_vanner Pancreas Centre BC BC Cancer #openaccess

🔥off the press: The use of immunotherapy pre-liver transplant Journal of Hepatology authors.elsevier.com/c/1kNgCcOnAUhMK 👉Hepatology Snapshot 👉Our thoughts on the use of ICI before liver transplant in HCC 👉Food for thoughts.. ESMO - Eur. Oncology EASL Education ILCA #livertwitter

@NCICTEP_ClinRes SWOG Cancer Research Network CCTG #Coloncancer Task Force Chairs Smitha Krishnamurthi Jonathan Loree hard at work at Oral Presentation session ASCO #ASCOGI25 analyzing the LBA’s including BREAKWATER, CALGB80702, BESPOKE and CM 8HW. 👏 👏 💪💙

#GI25 ❤️ ASCO So proud to see our past and present #oncology trainees thriving & making their mark! Jp Solar Vasconcelos Jonathan Loree Cynthia Howie 🇨🇦 BC Cancer @UBCmedicine

New research: Neoadjuvant chemoradiotherapy followed by active surveillance versus standard surgery for #oesophagealcancer (SANO trial): a multicentre, stepped-wedge, cluster-randomised, non-inferiority, phase 3 trial thelancet.com/journals/lanon…

Just published in Journal of Clinical Oncology the updated ASCO guidelines on fertility preservation in people with #cancer: a must read for all colleagues involved in cancer care to increase awareness on #oncofertility issues OncoAlert Ann Partridge MD, MPH Oncofertility Link: ascopubs.org/doi/10.1200/JC…

12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak

Both hand cooling and compression were effective in preventing sensory chemotherapy-induced peripheral neuropathy during taxane-based chemotherapy. ja.ma/4ih0UDi @mbreckwoldt

Cell-free DNA (cfDNA) testing could improve colorectal cancer detection and reduce mortality in Canada, but it requires higher participation rates to be effective compared to current screening methods. ja.ma/4lUmTD1 Jonathan Loree

nejm.org/doi/full/10.10…

What if this was a drug ?🙂 🆕 NEJM | June 2025 🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer 📦 RCT | n=889 | Median FU: 7.9 yrs 🟠 3-yr structured aerobic program vs health ed alone 📈 Primary Endpoint: Disease-Free Survival (DFS) 🔹 HR 0.72