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Please to report that our study on dynamic gene regulation in #psoriasis #skin is now published in Nature Communications. Thanks to all of our colleagues and collaborators, the Immune Tolerance Network, and to Qian and Joseph! nature.com/articles/s4146…

Very excited to share our highly collaborative work as part of the NIAMS AMP-RA/SLE network. We mapped single cell tissue states in #rheumatoid #arthritis. nature.com/articles/s4158…

So excited to introduce GeNA - our statistically robust genome-wide single cell state association method! Already leading to key insights for multiple immune loci! Laurie Rumker Broad Institute Brigham and Women’s Research

Exciting day for the lab! Two papers out in Nature Genetics, both about integrating genetic data with single cell data! Special thanks to lead authors Anika Gupta and Joyce Kang rdcu.be/dsrz2 rdcu.be/dsrzB

Excited that our single-cell eQTL study of HLA genes is out now in Nature Genetics! ⭐️ nature.com/articles/s4158… Huge thx to Soumya Raychaudhuri সৌম্য রায়চৌধুরী Saori Sakaue Yang Luo for their guidance Check out this great News & Views by the Gaffney lab describing the key points: nature.com/articles/s4158…

A few thoughts on the recent set of papers torture testing genomic deep learning for predicting individual-level gene expression [ pubmed.ncbi.nlm.nih.gov/38036790/ , pubmed.ncbi.nlm.nih.gov/38036778/ , pubmed.ncbi.nlm.nih.gov/38036789/ ]. First a brief summary 🧵: x.com/SashaGusevPost…

🎉 Happy New Year! Exciting news: a new postdoc position is open in our lab! Interested? DM me for details. Application deadline: January 29. #KirDataSci #postdocjobs my.corehr.com/pls/uoxrecruit…

Exciting news! We have an amazing opportunity for a lab tech who can help us define the function of individual variants. If you are passionate about CRISPR editing of primary human cells please DM me ASAP! #genomics Brigham and Women’s Research Broad Institute partners.taleo.net/careersection/…

You can now get my book in Spanish! ¡¡¡TRIPLE BAM!!! statquest.org/statquest-stor…

Excited to share a review led by Kaitlyn A Lagattuta describing the relationship between human autoimmunity and T cell functional traits! nature.com/articles/s4146… Broad Institute Brigham and Women’s Research Aparna Nathan

I’m excited to share our latest work on enhancing the power to detect response expression quantitative trait loci (reQTLs) at single-cell resolution across different perturbations conditions: biorxiv.org/cgi/content/sh… with Soumya Raychaudhuri সৌম্য রায়চৌধুরী Broad Institute and co-authors 👇

This was peak software design

📢 New PhD opportunity! A unique programme where data and clinical scientists work together to unlock new drug targets. 💡🔬 Join our fully-funded programme at Kennedy Institute of Rheumatology! Apply now. DM me if you're interested. Please RT! ndorms.ox.ac.uk/study/kennedy-… #DPhil #PhDOpportunity #Oxford

Hi friends! Genotype-Neighborhood Associations (GeNA) by Laurie Rumker et al is now published! Broad Institute Brigham and Women’s Research nature.com/articles/s4158…

This is eugenics. As President of the American Genetics Association and a human, I reject this. We are better than this. cnn.com/2024/10/07/pol…

Attending #ASHG24? Excited with new statistical genetics methods and analyzing data from newest functional genomics tech? Happy to chat if you are interested in joining my group UW Genome Sciences UW in beautiful Seattle next spring or later 🙂

I’m thrilled to share one of the largest single-cell transcriptomic atlas of the human DLPFC with over 6.3M nuclei from 1,494 unique brain donors. Collaboration with Mikaela Koutrouli Nick Gabriel Hoffman Jaroslav Bendl John Panos Roussos and #PsychAD Consortium doi.org/10.1101/2024.1…

Excited to share the final chapter my PhD research on medRxiv! eQTLs only explain 30% of GWAS loci and 11% of trait heritability. Here we investigate if epigenetic QTL can provide new insights at the remaining GWAS loci. medrxiv.org/content/10.110…

Excited to tell you about VIMA (Variational Inference-based Microniche Analysis), our deep learning + stats hybrid for case-control analysis of multi-sample spatial molecular datasets. 🧵👇biorxiv.org/content/10.110…. Soumya Raychaudhuri সৌম্য রায়চৌধুরী , Broad Institute , Brigham and Women’s Research

Check out our latest #DeepLearning method to analyze spatial molecular data from Yakir Reshef!