🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Hypothyroidism triggers cardiomyocyte necroptosis in heart failure, which can be reversed by Dusp14-mediated MLKL dephosphorylation ahajournals.org/doi/full/10.11…

CD206⁺IL-4Rα⁺ macrophages proliferate and drive adverse LV remodeling via FIZZ1-mediated fibrosis. IL-4Rα deletion or silencing reverses remodeling and improves function. A novel therapeutic target in ischemic cardiomyopathy ahajournals.org/doi/full/10.11…

Sumanth Prabhu, MD Qiongxin Wang, WashU Medicine Cardiovascular Division, WashU Medicine Department of Medicine, WashU Medicine

METTL3, an m6A methyltransferase for mRNA modification, mediates the exercise benefits in diabetic cardiomyopathy via a direct downstream effector, YBX1. Haobo LI, Ph.D. ahajournals.org/doi/full/10.11…

This study describes how genomic editing of a pathogenic mutation in ACTA2 restores key aortic smooth muscle functions, and life-threatening aortic dilation and dissection are mitigated in humanized mice. @volkersmirko @vietloandaothi ahajournals.org/doi/abs/10.116…

Factor XI inhibition in atrial fibrillation: it remians to be seen whether FXI inhibitors will match the efficacy of DOACs or VKAs in prevention of thromboembolic events. ahajournals.org/doi/full/10.11…

#Editorial on the potential of Olmesartan to restore LMNA function in haploinsufficient cardiomyocytes ahajournals.org/doi/full/10.11…

Partial Heart Transplantation: a comprehensive review of partial heart transplantation, including current status, clinical adaptation, and future directions.Neel Prabhu Joseph W Turek Michael Mensah-Mamfo ahajournals.org/doi/full/10.11…

The NHS Targeted Lung Health Check Programme reports a 1.3% diagnostic yield for incidental thoracic aortic dilation, with strong correlation to gated imaging. Raghav Bhatia Dalia ahajournals.org/doi/full/10.11…

#ICYMI: HFpEF Stem Cells Joseph hill Sanjiv J. Shah, MD Matthew Feinstein Pilar Alcaide, PhD Kris Glinton Gabriele G. Schiattarella Matt DeBerge

#ICYMI: Evolocumab in Autoimmune or Inflammatory Diseases André Zimerman @bweber04 ana laura kunzler @rgiuglaino

BREAKING: MAGA is losing their minds at this excellent speech delivered by 60 Minutes' Scott Pelley, slamming Trump for attacking pillars of democracy. “Law is under attack. Journalism is under attack. Universities are under attack.” Share widely.

ORION-13 #RCT In adolescents with homozygous FH, inclisiran was well tolerated and effective in reducing LDL-C ahajournals.org/doi/full/10.11…

15d-PGJ₂ blocks CaMKII via C495 lipoxidation, reducing I/R injury. A new endogenous CaMKII inhibitor and therapeutic target. ahajournals.org/doi/full/10.11…

Through whole exome sequencing, a novel pathogenic variant in cardiac troponin T was identified as a causal mutation in a familial dilated cardiomyopathy cohort. The mutation disrupted sarcomere-mitochondrial communication. ahajournals.org/doi/10.1161/CI…

A protein risk score derived from proteomics data improved risk prediction of AFib beyond that achieved from clinical risk factors, NT-pro BNP, & genetic risk. Proteins in the model were associated with atrial remodeling, ECM turnover, & inflammation. ahajournals.org/doi/full/10.11…

In pts w/ desmosomal gene variants, mutational hotspots associated with higher risk of life-threatening arrhythmic events & end-stage HF were identified, highlighting the value of genotype-based approaches in understanding clinical trajectories. ahajournals.org/doi/full/10.11…

#ICYMI: PCSK9 inhibits SNX17-mediated LDLR recycling #AHAJournals

#ICYMI: P. gingivalis translocation and atrial fibrosis/AF #AHAJournals

Congratulations to Josh Beckman, whose visionary leadership as chair of the AHA/ACC Joint Committee on Clinical Practice Guidelines makes him more than deserving to be honored with an Award of Meritorious Achievement. The improvements Dr. Beckman spearheaded in the guidelines