EPCO-31 - Epigenomic intratumoral heterogeneity of glioblastoma in three-dimensional space cdmcd.co/rXnw7R #sno2020

Check out our paper on modeling TERT promoter mutation in our iPSC-derived GBM avatar platform. Congrats Dr. Shun Miki on generating this informative model! Excellent collaboration w/ @JosephCostell14 National Brain Tumor Society SNO NIHBrainTumor UCSD Division of Regenerative Medicine academic.oup.com/neuro-oncology…

Here with Nicholas Stevers UCSF Neurosurgery still time to view his poster [section 5 #6] on “Intrinsic resistance to targeting tumor cell immortality conferred by multiple GABP complexes” #AACR22

2 postdoc positions available in the Costello lab at UCSF! Interested in basic and translational research in tumor evolution and tumor cell immortality? Email [email protected]

Abigail Suwala Carter Barger Joe Costello et al. identify #TERT promoter duplications across seven cancer types that are functionally equivalent to hotspot TERT mutations and are clonal in multifocal #glioblastoma #CancerResearch @natrescancer go.nature.com/3dtzeA0

Thrilled to finally share my 5+ years of postdoctoral work, published today in Cell! “Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective” Cell Joe Costello UCSF Neurosurgery UC San Francisco authors.elsevier.com/c/1iS4bL7PXmefE

We identified many tumor-wide therapeutic targets that may circumvent heterogeneity-related failures. We also created an online platform for users to explore our 3D spatial map of GBM and interrogate heterogeneity of user-selected genes and programs: 3d-gbms.shinyapps.io/search/

Thank you to all our amazing collaborators on this project including Feng Yue from Northwestern Feinberg School of Medicine, @MarcoGalloLab and Dr. Ana Nikolic, Nicholas Stevers, Darwin Kwok, and many more!

Also very excited to see our work featured in Cell Leading Edge by the @Winkler_Lab! Thank you for summarizing our work and highlighting its importance so beautifully! sciencedirect.com/science/articl…

We are excited to share our new publication! It is a multi-year, multidisciplinary basic science and clinical team effort. Thank you Dept of Neurosurgery and UCSF Brain Tumor Center for making this possible! Radhika Mathur et al, Cell, Jan 18, 2024 cell.com/cell/fulltext/…

Visit the "whole tumor" data from Mathur et al, Cell, 2024 in a user friendly format: 3d-gbms.shinyapps.io/search/ and see Cell Leading Edge article by Baig and Winkler, Cell, Jan 18, 2024 cell.com/cell/fulltext/…

Published today in Cell: Researchers, led by Radhika Mathur, PhD, Feng Yue, & Joe Costello, use a unique tumor sampling approach to offer a 3D view of #glioblastoma that identifies new potential therapeutic targets. cell.com/cell/fulltext/…

So proud of you Nick Stevers! 2024 Mentoring Award Winner for Predocs and Postdocs, from the UCSF Dean’s office!

Hideho and I are very proud of you Darwin Kwok! 2024 Mentoring Award Honorable Mention for Predocs and Postdocs, from the UCSF Dean’s office!

Just setting up my Twitter. #myfirstTweet