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"The things I've learnt in Yong Loo Lin School of Medicine bear a strong influence on what I currently do." - Teo Chong Boon Tap on the link below to accept your NUS offer! tinyurl.com/NUSAcceptance #joiNUS #WriteYourFuture #ShapeYourFuture #NUSAdmissions

“just a little more reading then I can start writing”

Very cool abstract by ADJ lab CSI Singapore Anand D Jeyasekharan ATR inhibition with gemcitabine suppresses a BCL6-regulated transcriptional program, reversing dark zone signature in DLBCL ashpublications.org/blood/article/…

Multiomic analyses of #GastricCancer peritoneal metastases reveal distinct phenotypic features of metastases, highlighting the role of the TME & immune response in metastatic spread. 🖋️ Raghav Sundar 🔗 ow.ly/h3Il50UomTe

Spatially resolved tumor ecosystems and cell states in gastric adenocarcinoma progression and evolution aacrjournals.org/cancerdiscover…

So proud of Joseph J Zhao who won a merit award at ASCO GI 2025 for his work on profiling the tumor microenvironment of colorectal cancer peritoneal metastases!

Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors jitc.bmj.com/content/13/2/e… Filippo Pietrantonio Vincenzo Nasca Raghav Sundar Sara Lonardi Journal for ImmunoTherapy of Cancer

Shifting focus to B-cells in gastric cancer: Our study examines multiple cohorts and employs spatial profiling. This provides fresh insights into the tumor microenvironment, complementing T-cell focused studies of the TME link.springer.com/article/10.100… Ryan Yong Kiat Tay Joseph J Zhao

🔥 Interesting pre-print on how Chk1-Sp1-CD59 axis impedes rituximab mediated complement-dependent cytotoxicity biorxiv.org/content/10.110… Congratulations to the team! Anand D Jeyasekharan [email protected] NCIS CSI Singapore Chng Wee Joo

🧬 The Chk1-Sp1-CD59 axis weakens rituximab ability to kill lymphoma cells by impairing Complement-dependent cytotoxicity. Targeting this pathway could enhance chemoimmunotherapy outcomes. CSI Singapore Anand D Jeyasekharan 🔬#Complement #Immunotherapy #DLBCL Link: doi.org/10.1101/2025.0…

Excited to share biomarker analysis of CM649 Nature Medicine Yelena Y. Janjigian MD Nivo benefit was enriched in TMB-H> EBV and GS > CIN. Targeted tx is needed for CIN. Nivo+Ipi benefit was seen in Treg↑ (FOXP3+CCR8), supporting Treg or CCR8 targeting tx in GC. nature.com/articles/s4159…

I can't get over these 3D spatial images in the latest preprint from Peter Sorger Ajit Johnson Nirmal et al. The preprint is a roadmap on how to conduct 3D cyclic immunofluorescence using "thick" archival sections and precisely map cell-cell interactions biorxiv.org/content/10.110…

Thrilled to share our latest study just out in nature 😄A major milestone in our collaboration with ⁦Anirban Maitra⁩ Led by brilliant ⁦⁦⁦Guangsheng Pei⁩ ⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦⁦Jimin Min⁩ ⁦⁦MD Anderson Cancer Center⁩ nature.com/articles/s4158…

At yesterday's opening ceremony, we asked the cancer community to stand together to make their voices heard in support of innovative cancer science and medicine. #CancerResearchSavesLives® #AACR25

Published today simultaneously with #AACR25 our work on colorectal cancer peritoneal metastases in Clinical Cancer Research. aacrjournals.org/clincancerres/… slowly heading toward the goal of treating this difficult disease with novel therapeutics

String of #AACR25 posts coming up! Proud of the work by Joseph J Zhao unraveling epigenetic mechanisms of peritoneal metastases in gastroesophageal cancers. Sam Klempner Ong Chin-Ann Johnny

Thrilled to share our latest Review on Gastric Cancer in the The Lancet covering the latest in the treatment and management of this illness Lizzy Smyth Kohei shitara Hanneke van Laarhoven Sheraz Markar Yelena Y. Janjigian MD & Izuma Nakayama. thelancet.com/journals/lance…

Impressive work by Dr Allison Chan from ADJ Lab at CSI Singapore on a novel interplay between genotoxic chemotherapy and CDC💥💥 Anand D Jeyasekharan [email protected] #InternationalCellDeathSociety2025 #ICDS2025