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If we want to thoughtfully reduce NIH indirect costs, we need to reduce the federal regulatory burden that causes universities to hire so many administrators to remain compliant.

1/5 Sharing our Clinical Cancer Research work establishing serum CA-125 as a biomarker for #RenalMedullaryCarcinoma. This is now the first cancer-associated blood biomarker to become standard of care and used globally for a #kidneycancer : aacrjournals.org/clincancerres/… The V Foundation for Cancer Research Chris Johnson Foundation Inc.

Helpful to characterize this clearly distinct subgroup of lung cancer clinically and molecularly. Important work.

Great precision oncology study from A pancreatic cancer doctor and team

dailynews.ascopubs.org/do/appendix-ca… Thanks to #ascodailynews and ASCO for publishing our commentary on appendix cancer. Turns out not the same as colon cancer! Please help spread the word.

Cancer vulnerabilities exposed by finding interactions among DNA repair factors nature.com/articles/d4158… Robert W. Sobol Benedito A. Carneiro, MD, MS

ICYMI: John Paul Shen of MD Anderson Cancer Center and Mike Foote of Memorial Sloan Kettering Cancer Center discuss how appendix cancer differs from CRC and examine new potential targeted treatments: brnw.ch/21wS5hM #ASCODailyNews

Attending #AACR25 ? Curious about #KRAS inhibition in rare tumors? Come visit our poster! We share exciting preclinical data with MRTX1133 and RMC-6236 in organoid and PDX models of #AppendicealCancer MD Anderson Cancer Center

👏 Huge kudos to Andy Wang for brilliantly leading the SLIDE-EX project—all accomplished during his summer internship! Mentored by Eldad Shulman in collab with Saugato Rahman Dhruba, Kun Wang, and Emma Campagnolo. Full preprint👇🧵8/8 biorxiv.org/content/10.110… #AI #DigitalPathology

Important publicly available resource from Tirosh Lab Weizmann Institute in Nature Cancer The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution nature.com/articles/s4301… 124 single cell datasets across 40 cancers, >2800 samples.

HUGE congratulations to Scott Kopetz MD Anderson Cancer Center who will lead a multi-institutional consortium (CRC-ASCEND) on implementing adaptive clinical trials in #ColorectalCancer. Kudos to the whole team, including oncologists, program managers and patient advocates. A.n.n.

Couldn’t agree more - it’s critical to send molecular profiling studies for rare tumors. For appendix cancer profiling the TME in addition to tumor is going to help identify the best ways to use novel immune therapies

Another example of TME modifying immune response

Great resource- kudos to authors for putting out this pre print and making data available

Thank you Cancer Today AACR for featuring our recent ESMO - Eur. Oncology Real World Data & Digital Oncology study on the portrayal of cancer in public figures in news stories. The public should be cognizant that many news articles lack pertinent details on an individual's diagnosis,

I'm thrilled to share our new meta-analysis! Primarily including CRC and pancreatic cancer patients, it shows that omitting 5-FU bolus from chemotherapy regimens maintains PFS and OS while reducing risks of G3-4 neutropenia and thrombocytopenia. tandfonline.com/doi/full/10.10…

Zanidatamab plus chemotherapy as first-line treatment for HER2-positive GC/GEJ cancer The Lancet Oncology doi.org/10.1016/S1470-… 🔎single-arm, phs 2 👉ORR 76·2% 👉mPFS 12·5 mo 👉mOS 36·5 mo 🧐Looks promising, now combo w/ ICI, phs-3 awaited ESMO - Eur. Oncology

✍️ Writing is thinking. 👉🏼A powerful editorial in Nature Reviews Bioengineering (Vol. 3, p. 431, 2025) reminds us of something timeless: in science, writing is far more than reporting results. It’s a way of sharpening thought. 👉🏼Even in an age shaped by large-language models,

Implications of BRAF V600E in dMMR/MSI-H pts treated with ICIs. Prognostic impact of the BRAF V600E mutation in patients with MSI-high... sciencedirect.com/science/articl… AACR Journal of Clinical Oncology ASCO Mayo Clinic Comprehensive Cancer Center

Another new paper out! Grateful to have been a part of the effort. We (Andrew Pellatt and Arvind Dasari) asked: Can TAS-102 eliminate ctDNA-defined MRD in CRC after adjuvant chemo? 💊 Single-arm phase II study of CRC pts with MRD by ctDNA after curative-intent therapy (Stage