Interesting

Great opportunity and super interesting science 👇

Excited to share "Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution", from an amazing collaboration with Dan Landau Andrew R. D’Avino Tamara Prieto Toshiro Hara Mario Suva! A tweetorial, or Xplanation ... nature.com/articles/s4158…

Immune surveillance of cancers is thought to be an important force shaping tumour evolution. Is the same true of somatic evolution in general? Does the adaptive immune system “see” non-self clonal expansions and eliminate them? A:👇 by Babrara Walkowiak biorxiv.org/content/10.110…

Doing good science is 90% finding a science buddy to constantly talk to about the project.

PhD and Postdoc positions available! Interested in how our immune system evolves with a growing tumour, and how we can use that to fight cancer? Love data analysis? Applications now being accepted in the Machado Lab (machado-lab.org/contact) at the University of Cambridge.

Stem cell transplants are amazing. A patient's diseased blood is replaced by a relative or stranger's. But what does putting a blood system into a new body do to the cells? How many survive? Does it matter? Out in nature today, we asked some basic Qs 👇 rdcu.be/dYCoZ

Most exciting event of spring 2025! Please come join us!

Our work on contrastive learning of T cell receptor representations is now out in Cell Systems! Give SCEPTR embeddings a try for your TCR analysis applications: sceptr.readthedocs.io/en/stable/

Delighted to share our latest work exploring levels of selection operating during pre-cancerous evolution usng single-cell DNA sequencing of HSCs led by the outstanding gladyspoon cell.com/cell-genomics/…

Knudson’s “Two-Hit” Hypothesis and Cancer Predisposition: A Bit More Complicated but Still Going Strong ⁦Cancer Discovery⁩ aacrjournals.org/cancerdiscover…

Out today in nature our study of long-lived T cell responses to personalized neoantigen vaccines in #PDAC led by Zach Sethna & Pablo Guasp. Read the summary below by Vinod BalachandranMD Memorial Sloan Kettering Cancer Center 👇👇👇 nature.com/articles/s4158…

So happy that I can finally share the results of my first postdoc paper with Michael Baym!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! Here’s a photo of plasmids competing inside cells in a colony (1/n)

🚀 Exciting Announcement: Monthly Webinar Series 🚀 I am delighted to launch our new monthly webinar series: 🔬 Unravelling T Cell Recognition: Insights from Immunology and AI

Great to see this out! Well done to the entire team 💪

Delighted to share a major update on our work investigating age-related deceleration in clonal haematopoiesis. Takehome: Widespread and substantial deceleration in fitness with age! Amazing effort by PhD student Hamish MacGregor 💪 biorxiv.org/content/10.110…

The potency of abnormal genetic fusion in chronic myeloid leukaemia in our latest study nature 👉🏽 nature.com/articles/s4158… This cancer is an oddity - one of the few single genetic “hit” cancers, a short trajectory (few years) from start to diagnosis, and explosive growth.

Amazing work Elli and team!

science.org/doi/abs/10.112…

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx. By brilliant Adriana Fonseca ✅Early cancer ✅Methylation drivers ✅Epimutation rates ✅CpG lineage tracing biorxiv.org/content/10.110…