New to Nature Communications, we review how non-coding RNAs, transposons, microproteins, and other functional elements besides canonical ORFs contribute to fitness across the fungal kingdom, and the new tools we have to characterize them Rebecca Shapiro (nature.com/articles/s4146…)

Human and other primate hearts differ genetically | A study from the Hübner and Sebastian Diecke labs at #mdcBerlin reveals evolutionary adaptations in human hearts and provides new insights into cardiac disease: mdc-berlin.de/news/press/hum… Nature Cardiovascular Research J Ruiz Orera

Part 1 of our venture into the world of alternative translation-linked proteoforms! (Now Dr) Paul Lee, Yu Sun, along w/Alexa Soares and others in Marina Picciotto lab found that alternative TIS pairs change the localization and functions of synaptic organizers! authors.elsevier.com/a/1jpc73vVUPRm…

New 📜 in NatureStructMolBiol - "Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity", by Sveta in my lab, Omer Ziv Eric Miska and Lau and Greg Kudla lab. Been a while since preprint, so a 🧵 nature.com/articles/s4159…

Research| Ruiz-Orera et al. explored cardiac translational evolution in primates and mammals. They identified newly evolved genes and #sORF unique to humans, suggesting these genetic innovations may influence #heart development and disease J Ruiz Orera 👉 rdcu.be/dVBb3

We have several open positions in our lab. If you are passionate about proteins and AI, come join us at an excellent location at Centre for Genomic Regulation (CRG) Biomedicina BCN ! aiproteindesign.com/jointhelab

🧬🚨New in Trends in Genetics: Our review on microproteins in cancer! From identification to clinical potential, discover how these tiny proteins are reshaping cancer biology here: authors.elsevier.com/sd/article/S01… @s_heesch @johnprensner #microproteins #CancerResearch

Our latest: Orphan genes are not a distinct biological entity. Orphan genes, aka loci with no homologous genes outside a focal taxon, are widely used as proxies of lineage-specific genes that are important for adaptation and innovation. onlinelibrary.wiley.com/doi/10.1002/bi…

We are looking for a biocatalyst/protein engineer to establish high-throughput assays for our AI-designed enzymes. Join our mission in an excellent location/resources and drop me a message anytime if you'd like to know more :)! tinyurl.com/5dhxphb6

I am very proud to share that our ‘epitranscriptomic fingerprinting’ manuscript is now published in Molecular Cell ! You can access the article here: authors.elsevier.com/c/1kF253vVUPRn…; for highlights see the thread below. (1/11)

Not easy to describe the emotions of seeing our work published in Cell ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins. dlvr.it/TGkWYB

Excited to share our review article "Finding functional microproteins", published in Trends in Genetics. It was fun writing it together with Alex and Feiyue Yang in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJBLQb

Our updated preprint on the mechanism behind the 1st & only human disease linked to tissue-specific ribosome: fatal heart failure caused by RPL3L mutations. Very proud of this work led by the talented and fearless Michael Murphy Michael Murphy—check out his thread for more details!

TiG's February issue is devoted to microproteins and the small ORFs that encode them. Check it out! cell.com/trends/genetic…

In our new paper in Trends in Genetics Cell Press, we highlight some fascinating tiny proteins—microproteins—which appear to be widespread in nature. These small but mighty molecules can influence interactions within and between species, potentially reshaping entire microbial

Desde la SEBIBC, nos complace informarle de la celebración de la III Jornada BIOINFORMÁTICA EN ARAGÓN 📅 Fecha y horario: 14/02/25, de 09:00 a 17:00 h 👥 Plazas disponibles: 150 📆 Plazo de inscripción: del 20/01 al 12/02 de 2025 Mas info en el link 👇geyseco.trckacbm.com/url/ver/745792…

happy to see this out! great team effort to integrate data from disparate studies, increasing our knowledge on the response to immunotherapy depending on tumor subtype Bioinformatics GRIB HMar Research Institute UPF Medicine and Life Sciences

Excited to share our review published in Circulation Research highlighting how recent technological advancements have transformed our understanding of interorgan signaling! Check it out: ahajournals.org/doi/10.1161/CI…

Exciting opportunity for researchers passionate about #mitochondria. Join us at Duke-NUS Medical School to explore mitochondrial #microproteins in metabolic control. Use AI to uncover therapeutic targets for metabolic diseases from the microproteome. Mitochondria News nature.com/naturecareers/…

Rockefeller's Li Zhao has spent nearly a decade cataloguing evolutionarily young genes. Now, complementary studies in PNASNews and NatureEcoEvo are the first to demonstrate how these new genes are regulated and expressed. rockefeller.edu/news/38025-how…