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Effect of Cumulative Exposure to Ocrelizumab on Memory B-Cell Repopulation Dynamics in Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1002/an…

1st paper out as the senior author, fittingly it is the revamped scRepertoire: building a more comprehensive and efficient single-cell immune profiling ecosystem!! Large thanks to my co-authors KelvinTuong and others Paper: journals.plos.org/ploscompbiol/a… Repo: github.com/BorchLab/scRep…

Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype biorxiv.org/content/10.110… #biorxiv_immuno

Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells Nature Communications Ines Sturmlechner nature.com/articles/s4146…

Our new AIRR paper alongside Ocrelizumab, thanks to NFDI4Immuno - @[email protected] and the whole team! cell.com/iscience/fullt…

Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers Nature Communications nature.com/articles/s4146…

Online now: Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse dlvr.it/TLwz5w

"Enhancing sequence alignment of adaptive immune receptors through multi-task deep learning" by Gur Yaari lab. Very promising: speed boost from GPU acceleration + solving problems of greedy aligners in capturing V(D)J rearrangement uncertainty academic.oup.com/nar/article/53…

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 jni-journal.com/article/S0165-…

Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms frontiersin.org/journals/neuro…

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity science.org/doi/10.1126/sc…

Happy to share Syc-Mazurek et al study of attack & remission MRI in #MOGAD vs #MS ➡️ Resolution of 1 lesion predicts #MOGAD and disappearance of ≥2 lesions separates #MOGAD completely from #MS ➡️ MRI 1 yr post #MOGAD brain/spine attack may aid diagnosis👇jnnp.bmj.com/content/early/…

New online! Advancing multiple sclerosis management in older adults bit.ly/3IIZRQM

TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes biorxiv.org/content/10.110… #biorxiv_immuno

Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice science.org/doi/10.1126/sc…

🤯Three (!!!) new papers today in Science Magazine on the application of generative AI for the de novo design of peptide/HLA binding molecules! Completely unique 3D structure and binding mode compared with natural TCRs and TCR mimics! Links to papers 👇

CD20+ T Cells in Multiple Sclerosis: From Pathogenesis to Treatment-Induced Depletion mdpi.com/1422-0067/26/1…

Host control of latent Epstein-Barr virus infection medrxiv.org/content/10.110…

HHV-6 and EBV reactivation in relapsing remitting multiple sclerosis: Disability, progression, and inflammation links sciencedirect.com/science/articl…

CD8+ T Cells You Should Know about in Autoimmunity: Current Paradigms of T Cell Pathogenesis in Autoimmune Disease link.springer.com/article/10.100…