🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Pathologists! Check out this case of lymphadenopathy related to a deteriorating knee replacement. Sheets of distinctive, histiocytes, with black particles in cytoplasm, representing metal wear debris. #hemepath #histiocytes

Pathologists! One week until CCSP kicks off! I hope you will join us for this livestream event.

#MassGeneralPathology residents have gone all out, decorating the residents’ room for #Halloween! Imagine signing out with a bloody skull over your left shoulder.

Pathologists! Check out our open access review of Splenic B-cell lymphomas at this link: doi.org/10.1111/his.15… #spleen #lymphoma

Pathologists! What is your differential diagnosis for this lesion on the lower leg of an elderly individual? What immunostains would help? #hemepath #dermpath #Dermatology

Good morning! The diagnosis is primary cutaneous diffuse large B-cell lymphoma, leg type. The anatomic site, patient age, histology, and non-GCB immuno phenotype are classic. #Lymphoma

Pathologists! The weekend is here. Take a break and have a look at this nice example of something rare: Langerhans cell histiocytosis of the uterine cervix. #histiocytes #Hemepath #GYNPath

Pathologists! What is your differential diagnosis for this symptomatic lesion of the spinal cord in a middle-aged female? What immunostains or special studies might help you? Hint: CNS involvement is common, although spinal cord is an unusual site. #HemePath

Pathologists! This is a difficult case but my diagnosis is ALK positive histiocytosis. Take home point: consider staining for ALK when you have an unusual histiocytic infiltrate. #hemepath #histiocytes

Pathologists! Here is a classic case of Burkitt lymphoma, EBV+, presenting as a nasopharyngeal mass in a little boy. Fortunately, therapy is good and the prognosis is favorable. #Hemepath #Lymphoma

Pathologists! What is your differential for this right axillary lymph node in a 70 yo male? Histology and IHC are good for classic Hodgkin lymphoma (although CD15 is negative), except that some of the HRS cells appear CD3+, and many are strongly CD4+. Any other tests to request?

My diagnosis is CHL with aberrant T antigen expression. Please see attached with ancillary studies.

Pathologists! What is your Dx for this needle biopsy of an axillary lymph node from older adult male with widespread lymphadenopathy? #hemepath #lymphoma #EBV

This was a hard case. I said: EBV+ B lineage lymphoma, most consistent with EBV+ DLBCL. Histology looked OK for classic Hodgkin lymphoma but with so many B-lineage markers, I was afraid this was not CHL and would not respond to therapy for CHL. No evidence of abnormal T cells.

Pathologists! What do you think of this lymph node from 33 yo male with multifocal lymphadenopathy? What other work up would you do? #hemepath #lymphnodes

Here is some more IHC, attached. EBER and HHV8 were negative. Flow showed abnormal T cell population: CD3-, CD2 dim, CD4-, CD5+/-. Diagnosis? Underlying genetic change?

There was a typo on prior image; the image labeled LEF1 in lower right should be granzyme. Corrected image attached. Sorry! Now give me diagnosis and underlying genetic defect.

There is a reason that I did not choose hematopathology. 😁But even I understood this.

Spot on! This Alk negative anaplastic large cell lymphoma had a DUSP22 rearrangement. Clues are the positive LEF1 and absence of cytotoxic granules. #lymphoma #anaplasticlargecelllymphoma #hemepath

Colleagues, Please join us for Mass General’s GI pathology CME course, May 12-14, all virtual. nam04.safelinks.protection.outlook.com/?url=https%3A%…