Justin Deme (@justindeme85) 's Twitter Profile
Justin Deme

@justindeme85

Structural biologist, microbiologist, membrane protein scientist and cryo-EM enthusiast at NCI/NIH. Views are my own.

ID: 161789362

calendar_today01-07-2010 19:48:33

103 Tweet

223 Followers

206 Following

Tim Grant (@grantcryoemlab) 's Twitter Profile Photo

Can you fly protein complexes through native mass-spec, land them on EM grids and solve structures from them? Yes - you can! Here is recent work in collaboration with Coon Lab showing our preliminary NS results. Hopeful for cryo grids soon! biorxiv.org/content/10.110…

EMDB - EMPIAR @EBI (@emdb_empiar) 's Twitter Profile Photo

This 2.7 Å #singleparticle #cryoem structure of the yeast Sei1 protein informs our understanding of the formation of lipid droplets facilitated by the Sei1/Ldb16 complex. Nature Communications DOI: doi.org/10.1038/s41467… EMDB: ebi.ac.uk/emdb/EMD-13103 PDBe: ebi.ac.uk/pdbe/entry/pdb…

This 2.7 Å #singleparticle #cryoem structure of the yeast Sei1 protein informs our understanding of the formation of lipid droplets facilitated by the Sei1/Ldb16 complex. 
<a href="/NatureComms/">Nature Communications</a> 
DOI: doi.org/10.1038/s41467…
EMDB: ebi.ac.uk/emdb/EMD-13103
PDBe: ebi.ac.uk/pdbe/entry/pdb…
Simon Newstead (@inwardopen) 's Twitter Profile Photo

Read all about it - The molecular basis for cystine-glutamate antiport by System xc-, an important cancer target nature.com/articles/s4146… Another super collaboration with Susan Lea Justin Deme Phil Biggin 🇪🇺 and Dimitris Kolokouris & twitterless G Kuteyi & Jo Parker!

Rachel Harding (@labscribbles) 's Twitter Profile Photo

Hoorah! Our HTT-HAP40 manuscript is now published. Read about how we used multiple structural approaches to investigate HTT structure to further defined the relationship of HTT/HAP40 and the structural consequences of polyQ expansion on HTT-HAP40. nature.com/articles/s4200…

Hoorah! Our HTT-HAP40 manuscript is now published. Read about how we used multiple structural approaches to investigate HTT structure to further defined the relationship of HTT/HAP40 and the structural consequences of polyQ expansion on HTT-HAP40. nature.com/articles/s4200…
Communications Biology (@commsbio) 's Twitter Profile Photo

@labscribbles Cheryl Arrowsmith Susan Lea Justin Deme @hecklab @jcarroll42 describe the huntingtin (HTT) and HAP40 complex, demonstrating correlative abundance between the two and exploring conformational variety in the exon 1 region. nature.com/articles/s4200…

@labscribbles <a href="/CherylArrowsmi1/">Cheryl Arrowsmith</a> <a href="/S_M_Lea/">Susan Lea</a> <a href="/justindeme85/">Justin Deme</a> @hecklab @jcarroll42 describe the huntingtin (HTT) and HAP40 complex, demonstrating correlative abundance between the two and exploring conformational variety in the exon 1 region. nature.com/articles/s4200…
BactSecretionPapers (@secretionpapers) 's Twitter Profile Photo

Preprint: Structures of the #T9SS/gliding motility motor from across the phylum Bacteroidetes. - BioRxiv by Susan Lea biorxiv.org/content/10.110…

Cheryl Arrowsmith (@cherylarrowsmi1) 's Twitter Profile Photo

SGC-Toronto is looking for a Sr Research Assoc (PhD), & postdocs in structural biology, protein science & biophysics, comp chem related to antiviral drug discovery, #HuntingtonsDisease, cancer. Keep your eyes on thesgc.org/careers

Rachel Harding (@labscribbles) 's Twitter Profile Photo

Our latest preprint is now available on bioRxiv! We describe #opensource resources, validated by biophysical methods & cryoEM for investigating huntingtin structure-function. Thanks everyone for their hard work on this collaborative project! #openscience biorxiv.org/content/10.110…

Our latest preprint is now available on bioRxiv! We describe #opensource resources, validated by biophysical methods &amp; cryoEM for investigating huntingtin structure-function. Thanks everyone for their hard work on this collaborative project! #openscience biorxiv.org/content/10.110…
EMDB - EMPIAR @EBI (@emdb_empiar) 's Twitter Profile Photo

This weeks #EMDB release includes this beautiful 2.3 Å #SingleParticle #CryoEM structure of Helicobacter pylori UreFD/urease complex. EMDB: ebi.ac.uk/emdb/EMD-34648 Publication: europepmc.org/article/MED/37… Kam Bo Wong

Communications Biology (@commsbio) 's Twitter Profile Photo

Human, chicken, and Drosophila NOT1:NOT10:NOT11 ternary complexes have an evolutionarily conserved NOT10:11 module, hierarchical assembly of the complex. @ylevdan, @TobiasRaisch, @eugenevalkov, Susan Lea, @NCIResearchCtr and MPI Dortmund nature.com/articles/s4200…

Human, chicken, and Drosophila NOT1:NOT10:NOT11 ternary complexes have an evolutionarily conserved NOT10:11 module, hierarchical assembly of the complex. @ylevdan, @TobiasRaisch, @eugenevalkov, <a href="/S_M_Lea/">Susan Lea</a>, @NCIResearchCtr and <a href="/mpimoph/">MPI Dortmund</a> nature.com/articles/s4200…
Owain James Bryant (@oj_bryant) 's Twitter Profile Photo

Check out our new paper @ nature.com/articles/s4146… from my time working in the fantastic Chung lab ChungLab. Also check out our "Behind the Paper" post go.nature.com/3GCnE09. @ Filip Lastovka, ChungLab, @CamPathology, Owain James Bryant. More to come from us soon!

Stephen Garrett (@stephenrg97) 's Twitter Profile Photo

Very happy to share some work from my PhD which is now published in Nature Communications! We have identified a new type of T7SS substrate which has a strange ‘reverse’ secretion signal. doi.org/10.1038/s41467…

Susan Lea (@s_m_lea) 's Twitter Profile Photo

Published today Steve Johnson and Justin Deme story finally revealing the molecular basis for transmission of uni-directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s41564…

Nature Microbiology (@naturemicrobiol) 's Twitter Profile Photo

Also hot off the press! Our latest article on the structural analysis of protein transport by the T9SS is out now 👇nature.com/articles/s4156…

Membrane Protein PDB (@memprotpdb) 's Twitter Profile Photo

Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon | Nat Microbiol doi.org/10.1038/s41564…

Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon | Nat Microbiol

doi.org/10.1038/s41564…
Lea Lab (@lealabtweets) 's Twitter Profile Photo

Reducing the complexity of a fascinating molecular motor. Read our Behind the Paper blog, where we detail our journey to deciphering the structural basis for how bacterial flagella shift into reverse gear: communities.springernature.com/posts/let-slip…

Phil Biggin 🇪🇺 (@philbiggin) 's Twitter Profile Photo

Want to know why some antibiotics get across the membrane via Peptide Transporters and others don't? Your dreams have come true! Read it here: rdcu.be/dWuH2 Awesome collaboration with Simon Newstead, Susan Lea, Justin Deme, Jo Parker, Gabriel Kuteyi, Simon Lichtinger

Department of Biochemistry at Oxford University (@biochemoxford) 's Twitter Profile Photo

A study from the Berks lab @OxfordBiochemistry — 'A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota' — provides a major breakthrough in understanding outer membrane biogenesis in this important group of organisms. More ⬇️ buff.ly/4i5yJaY

A study from the Berks lab @OxfordBiochemistry — 'A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota' — provides a major breakthrough in understanding outer membrane biogenesis in this important group of organisms. More ⬇️ buff.ly/4i5yJaY