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Can you fly protein complexes through native mass-spec, land them on EM grids and solve structures from them? Yes - you can! Here is recent work in collaboration with Coon Lab showing our preliminary NS results. Hopeful for cryo grids soon! biorxiv.org/content/10.110…

This 2.7 Å #singleparticle #cryoem structure of the yeast Sei1 protein informs our understanding of the formation of lipid droplets facilitated by the Sei1/Ldb16 complex. Nature Communications DOI: doi.org/10.1038/s41467… EMDB: ebi.ac.uk/emdb/EMD-13103 PDBe: ebi.ac.uk/pdbe/entry/pdb…

Read all about it - The molecular basis for cystine-glutamate antiport by System xc-, an important cancer target nature.com/articles/s4146… Another super collaboration with Susan Lea Justin Deme Phil Biggin 🇪🇺 and Dimitris Kolokouris & twitterless G Kuteyi & Jo Parker!

Hoorah! Our HTT-HAP40 manuscript is now published. Read about how we used multiple structural approaches to investigate HTT structure to further defined the relationship of HTT/HAP40 and the structural consequences of polyQ expansion on HTT-HAP40. nature.com/articles/s4200…

@labscribbles Cheryl Arrowsmith Susan Lea Justin Deme @hecklab @jcarroll42 describe the huntingtin (HTT) and HAP40 complex, demonstrating correlative abundance between the two and exploring conformational variety in the exon 1 region. nature.com/articles/s4200…

Preprint: Structures of the #T9SS/gliding motility motor from across the phylum Bacteroidetes. - BioRxiv by Susan Lea biorxiv.org/content/10.110…

SGC-Toronto is looking for a Sr Research Assoc (PhD), & postdocs in structural biology, protein science & biophysics, comp chem related to antiviral drug discovery, #HuntingtonsDisease, cancer. Keep your eyes on thesgc.org/careers

Our latest preprint is now available on bioRxiv! We describe #opensource resources, validated by biophysical methods & cryoEM for investigating huntingtin structure-function. Thanks everyone for their hard work on this collaborative project! #openscience biorxiv.org/content/10.110…

This weeks #EMDB release includes this beautiful 2.3 Å #SingleParticle #CryoEM structure of Helicobacter pylori UreFD/urease complex. EMDB: ebi.ac.uk/emdb/EMD-34648 Publication: europepmc.org/article/MED/37… Kam Bo Wong

Human, chicken, and Drosophila NOT1:NOT10:NOT11 ternary complexes have an evolutionarily conserved NOT10:11 module, hierarchical assembly of the complex. @ylevdan, @TobiasRaisch, @eugenevalkov, Susan Lea, @NCIResearchCtr and MPI Dortmund nature.com/articles/s4200…

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40 dlvr.it/Svq2Sy

Check out our new paper @ nature.com/articles/s4146… from my time working in the fantastic Chung lab ChungLab. Also check out our "Behind the Paper" post go.nature.com/3GCnE09. @ Filip Lastovka, ChungLab, @CamPathology, Owain James Bryant. More to come from us soon!

Very happy to share some work from my PhD which is now published in Nature Communications! We have identified a new type of T7SS substrate which has a strange ‘reverse’ secretion signal. doi.org/10.1038/s41467…

Published today Steve Johnson and Justin Deme story finally revealing the molecular basis for transmission of uni-directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s41564…

Also hot off the press! Our latest article on the structural analysis of protein transport by the T9SS is out now 👇nature.com/articles/s4156…

Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon | Nat Microbiol doi.org/10.1038/s41564…

Reducing the complexity of a fascinating molecular motor. Read our Behind the Paper blog, where we detail our journey to deciphering the structural basis for how bacterial flagella shift into reverse gear: communities.springernature.com/posts/let-slip…

Want to know why some antibiotics get across the membrane via Peptide Transporters and others don't? Your dreams have come true! Read it here: rdcu.be/dWuH2 Awesome collaboration with Simon Newstead, Susan Lea, Justin Deme, Jo Parker, Gabriel Kuteyi, Simon Lichtinger

Structural basis for antibiotic transport and inhibition in PepT2 | Nat Commun doi.org/10.1038/s41467…

A study from the Berks lab @OxfordBiochemistry — 'A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota' — provides a major breakthrough in understanding outer membrane biogenesis in this important group of organisms. More ⬇️ buff.ly/4i5yJaY