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Treatment with bacteria may be the potential treasure trove to treat insulin resistance, thus preventing diabetes. nature.com/articles/s4158…

"Translocation of gut commensal bacteria to the brain" biorxiv.org/content/10.110…

Scientists identified a potential macrophage target in white fat and depletion of this population in mice prevented weight gain, reduced inflammation, and protected against #obesity. science.org/doi/10.1126/sc…

"Identification of an alternative triglyceride biosynthesis pathway" nature.com/articles/s4158…

Yale researcher identified reduced brain response to nutrients observed in people with obesity, and notably this brain response is not recovered after weight loss. nature.com/articles/s4225…

The single cell analysis of the human pancreas informs the heterogeneity of endocrine cells and progenitors. nature.com/articles/s4146…

Leukocytes carrying CHIP mutations have been detected in human atherosclerotic plaques. medrxiv.org/content/10.110…

Plaque proteomics redefined patient stratification with distinct outcomes, categorizing subgroups of male and female patients with heightened risk of future cardiovascular events. ahajournals.org/doi/10.1161/CI…

Maturity-onset diabetes of the young (MODY3) is a monogenic hereditary diabetes caused by mutations in the transcription factor HNF1A. sciencedirect.com/science/articl…

An autosomal dominant mitochondrial uncoupling syndrome with hyper-metabolism. Exome analysis demonstrates a de novo heterozygous variant in ATP5F1B encoding the β subunit of mitochondrial ATP synthase. nejm.org/doi/full/10.10…

The study finds that diets enriched in poorly absorbed long-chain saturated fatty acids modulate gut microbiota independent of fiber intake, thereby leading to improved metabolism and decreased liver steatosis. nature.com/articles/s4146…

Pericytes and smooth muscle cell-driven safeguard toward maintaining the homeostatic vascular macrophage niche to curb inflammation in the atherosclerotic plaques. sciencedirect.com/science/articl…

Mechanistic insights from single cell study how clonal hematopoiesis promotes inflammation. nature.com/articles/s4416…

New results inform that hematopoietic stem cell subset develops memory of prior inflammation which is linked to human aging and clonal hematopoiesis. biorxiv.org/content/10.110…

❤️The September issue is out❤️ Read how #clonal_hematopoiesis promotes #inflammation at the single-cell level promoting #heart_failure and #atherosclerosis, the role of #lipid remodeling in #megakaryocyte differentiation and #platelet biogenesis and more! nature.com/natcardiovascr…

Harnessing the insights from single-cell and spatial omics platforms to understand normal physiology and diseases. grc.org/single-cell-ge…

Newly launched platform on Genome Wide Association Study (GWAS) for South Asian ancestry that is underrepresented in most of the GWAS. Please spread the words to serve the underserved. Become a participant here: ourhealthstudy.org

I am grateful to be part of the insightful work and learn new biology. Herein, the study reports that midlobular and pericentral hepatocytes clonally expand during hepatic regeneration. Congratulations to Inma Ruz Maldonado for spearheading the wonderful work. nature.com/articles/s4146…

Dedifferentiated early postnatal lung myofibroblasts redifferentiate in adult disease. DanielGreifLab Yale CVRC Yale School of Medicine. frontiersin.org/articles/10.33…

Hacking the immune system could slow down aging. Our immune system goes awry over time, and harnessing new knowledge from the altered immune system may encapsulate the novel elixir to treat age-related pathologies. nature.com/articles/s4158…