🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

How are mRNAs recruited to the ribosome small subunit in bacteria? Super cool story highlighting the role of bS1. Long standing basic questions answered there 🔬 science.org/doi/10.1126/sc…

SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities. Check out our new paper at: nature.com/articles/s4146… + movie

First paper of our lab today nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! EMBL doi.org/10.1038/s41586…

We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! biorxiv.org/content/10.110… 🧵 (1/7)

Thrilled to share our latest work: native cryo-EM structure of the Dystrophin-Glycoprotein Complex (DGC) is now published in Nature! nature.com/articles/s4158… This discovery sheds new light on the molecular basis of muscular dystrophies and pave the way to novel therapies.

Very happy our paper on Zorya anti-phage defense system is now published in nature! 🥳 Big congrats to first authors haidai HU and Philipp Popp and all other authors! Wonderful collab with Marc Erhardt and SimonJackson #cryoEM CPRatUCPH Københavns Uni nature.com/articles/s4158…

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert tinyurl.com/setd2

I am excited to share our discovery on how the Fe-rich eukaryotic Photosystem I (PSI) has an additional LHCI tetramer in Fe starvation from two green algae species isolated from drastically different environmental niches. biorxiv.org/cgi/content/sh…

The peer-reviewed version of our paper on human tRNA 3' processing is now published in NatureStructMolBiol. Many thanks to the reviewers for their constructive comments! nature.com/articles/s4159… See also the very nice related work by Martin Hällberg Genis Valentin: embopress.org/doi/full/10.10…

Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: science.org/doi/10.1126/sc…

RNA-guided systems span kingdoms, from bacterial immunity to eukaryotic gene regulation. How did they evolve? We traced the origins of CRISPR-Cas13 and identified its likely ancestor: an RNA-based toxin-antitoxin (TA) system. Here’s what we uncovered: cell.com/cell/fulltext/… 1/8

So happy that I can finally share the results of my first postdoc paper with Michael Baym!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! Here’s a photo of plasmids competing inside cells in a colony (1/n)

It is finally out! Muntathar Al-Shimary, Doudna Lab, Brady Cress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check out the final paper in Nature Microbiology nature.com/articles/s4156…

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

The sequel to our DRT2 story is here, and this one is once again full of surprises! This time around, the Sternberg Lab teamed up with the Wiedenheft Lab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: biorxiv.org/content/10.110…

🔬 New from the Farnung Lab: We have established a fully in vitro reconstituted chromatin replication system and we report the first cryo-EM snapshots of the human replisome engaging nucleosomes. 🧬✨tinyurl.com/replisome

So excited to share our new paper out today in nature. We repurposed R2 retrotransposons to create STITCHR, a tool that can make diverse edits in mammalian genomes including scarless multi-kilobase scale insertions nature.com/articles/s4158…

CRISPR continues to amaze me! Excited to share the last project from my PhD, co-led by the incredible Puja Majumder and myself! We studied the CRISPR effector Cat1, which forms beautiful filament networks to degrade NAD+. Out today in Science Magazine! science.org/doi/10.1126/sc…

Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…