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Hypertonic saline the easy winner compared to 20% mannitol both in terms of reducing ICP and raising CPP. A ‘no brainer’!

Damian Rowlands sums it up well. The unknown risk of school opening s NOT to children’s health but to society as a consequence of transmission to and by more vulnerable but exposed adults. The solution is more difficult as school closure is not cost neutral

Occam's razor: "the simplest explanation is usually right." What's more likely: all healthcare workers in the whole world are colluding in a mass conspiracy, or the virus is actually quite bad? We're not making it up, FFS. #PedsICU standing with our adult #ICU colleagues.

Disgraceful scenes in U.S. Congress. The United States stands for democracy around the world and it is now vital that there should be a peaceful and orderly transfer of power.

john pappachan liked Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden | NEJM nejm.org/doi/full/10.10…

Very well summarised Sam and well done to the whole team for this study. As you suggest a clinical effectiveness study would be good and although not ‘sexy’ very important in resource utilisation terms

Update of anaphylaxis from mRNA vaccines: 66 cases out of ~18 million vaccinations (=0.00000003%). All but 1 within 11 minutes. No deaths. JAMA jamanetwork.com/journals/jama/…

1)Does acidosis affect contractility of the neonatal heart? 2)And does bicarbonate help? 1) VERY LITTLE AND 2)NOT A LOT neonatalresearch.org/2020/01/27/doe… via NeonatalResearch

The conservatives have relegated fiscal prudence to the show cabinet Except when it comes to the NHS of course. Cartoon from @Spectator’s daily Covid-19 update. Sign up for free: spectator.co.uk/covid-19-updat…

Definately the way forward well done for getting this data out

Fantastic news Luise - well done #PedsICU@UHSFT

Charlotte Summers was particularly eloquent on Today. Greater the usual Winter pressures for ICU loom large. More long stay Covid patients and fewer staff

The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery | Elsevier Enhanced Reader reader.elsevier.com/reader/sd/pii/…

Early Active Mobilization during Mechanical Ventilation in the ICU | NEJM - Too much of a good thing?? nejm.org/doi/full/10.10…

nejm.org/doi/full/10.10…

Defibrillation Strategies for Refractory Ventricular Fibrillation | NEJM nejm.org/doi/full/10.10…

We recently asked for a Winchester architect to design an extension with a price limit of 300K. Guess what the first estimate for his design was?

It’s very reassuring that the Suella Braverman has confirmed that the police will not ignore you if ‘your HOUSE’ has been stolen. I feel very much safer🥱