Kapil Devkota (@kapil_devkota_) 's Twitter Profile
Kapil Devkota

@kapil_devkota_

postdoctoral researcher, Duke University

kapildevkota.bsky.social

ID: 1801338173395529728

calendar_today13-06-2024 19:38:00

171 Tweet

92 Followers

212 Following

Cranky Federalist (@crankyfed) 's Twitter Profile Photo

If I were Grand Vizier, I would simply never fall out of favor. I would always be in the emperor's good graces. I would never be blamed for bad policies. I would outsmart all of my rivals. I wouldn't be ousted. I simply wouldn't be.

Sasha Gusev (@sashagusevposts) 's Twitter Profile Photo

If I'm reading the new STATE ( Adduri et al. , arcinstitute.org/manuscripts/St… ) paper correctly, we still cannot predict the effect of genetic perturbations better than a simple mean, and many methods do worse?

If I'm reading the new STATE ( Adduri et al. , arcinstitute.org/manuscripts/St… ) paper correctly, we still cannot predict the effect of genetic perturbations better than a simple mean, and many methods do worse?
Anshul Kundaje (anshulkundaje@bluesky) (@anshulkundaje) 's Twitter Profile Photo

One thing that really bothers me with the new "virtual cell" terminology is that is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/

Ari Wagen (@ariwagen) 's Twitter Profile Photo

Chai Discovery (Joshua Meier Chai Discovery) just released Chai-2, a model for "zero-shot antibody design in a 24-well plate." The most existing result? Chai-2 successfully generated binders for 50% of the 52 targets they assayed (100x better than SOTA)! Some thoughts below:

Chai Discovery (<a href="/joshim5/">Joshua Meier</a> <a href="/chaidiscovery/">Chai Discovery</a>) just released Chai-2, a model for "zero-shot antibody design in a 24-well plate."

The most existing result? Chai-2 successfully generated binders for 50% of the 52 targets they assayed (100x better than SOTA)!

Some thoughts below:
Sergey Ovchinnikov (@sokrypton) 's Twitter Profile Photo

CASP is getting cut by NIH... 😢 (Anyone with extra funds wanna help support perhaps the most important competition of the century?) science.org/content/articl…

Giannis Daras (@giannis_daras) 's Twitter Profile Photo

Announcing Ambient Protein Diffusion, a state-of-the-art 17M-params generative model for protein structures. Diversity improves by 91% and designability by 26% over previous 200M SOTA model for long proteins. The trick? Treat low pLDDT AlphaFold predictions as low-quality data

Announcing Ambient Protein Diffusion, a state-of-the-art 17M-params generative model for protein structures.

Diversity improves by 91% and designability by 26% over previous 200M SOTA model for long proteins.

The trick? Treat low pLDDT AlphaFold predictions as low-quality data
Keyon Vafa (@keyonv) 's Twitter Profile Photo

Can an AI model predict perfectly and still have a terrible world model? What would that even mean? Our new ICML paper formalizes these questions One result tells the story: A transformer trained on 10M solar systems nails planetary orbits. But it botches gravitational laws 🧵

Peter Koo (@pkoo562) 's Twitter Profile Photo

Our work on "Evaluating the representational power of pre-trained DNA language models for regulatory genomics" led by Amber Tang with help from Nirali Somia & Steven Yu is finally published in Genome Biology! Check it out! genomebiology.biomedcentral.com/articles/10.11…

Rohit Singh (@rohitsingh8080) 's Twitter Profile Photo

Which of these images is not like the other and why does it matter for cancer research? That fourth transform is what real tissues need but most spatial methods can't handle. Enter SAME, our algorithm for integrating multimodal spatial omics across near-serial sections.

Which of these images is not like the other and why does it matter for cancer research? 

That fourth transform is what real tissues need but most spatial methods can't handle. 

Enter SAME, our algorithm for integrating multimodal spatial omics across near-serial sections.
Diva Jain (@divajain2) 's Twitter Profile Photo

India suffers not because the average Indian is mediocre, but because the Indian elite is mediocre. Instead of lifting all, they create little bubbles for themselves.

India suffers not because the average Indian is mediocre, but because the Indian elite is mediocre. Instead of lifting all, they create little bubbles for themselves.