Online Now: CCAR1 promotes DNA repair via alternative splicing dlvr.it/T96TsG

Paper by the Jacob Corn in collaboration with the Jonas lab (both D-BIOL @ ETH Zurich, ETH Zurich) & the @ZavolanLab (Biozentrum, University of Basel, University of Basel) w/ 1st author Erman Karasu (Erman KARASU) "CCAR1 promotes #DNA #repair via #alternative #splicing" Molecular Cell #RNA bit.ly/468Zwy7

Thanks to Abdel-Wahab Lab for the great Preview in Molecular Cell on work by Erman KARASU and Alan D'Andrea showing that CCAR1 regulates splicing for #FanconiAnemia and hundreds of other transcripts! Super clear overview of the papers. sciencedirect.com/science/articl…

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination bit.ly/4fKCvpV

🚨 Excited to share our latest paper in Cell identifying how under-replicated chromosomes in micronuclei become shattered by the Fanconi anemia pathway during mitosis. This work was led by UTSW Graduate School of Biomedical Sciences student Justin Engel. 🧵 (1/13): cell.com/cell/fulltext/…

Out in nature today! We report that a CDK5-cyclin B1 complex maintains proper cell division. We discovered that CDK5, a long regarded non-cell cycle CDK functioning only in neurons, yet overexpressed in many cancers, does regulate mitosis!  Link: nature.com/articles/s4158…

I'm looking for a #bioinformatician to join my group! Searching for someone collaborative & self-motivated with expertise in #NGS analysis. For example, functional genomics, #singlecell, splicing, RNA binding, lineage barcoding, ChIP-seq. Apply at jobs.ethz.ch/job/view/JOPG_…

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and Jacob Corn. Special shutout goes to @matthias_muhar nature.com/articles/s4158…

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! nature.com/articles/s4158…