🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Happy to share the final version of our #GAGEseq published today Nature Genetics! The single-cell co-assay for #scHiC and #scRNA reveals 3D genome & gene expression interplay in mouse cortex (also integration w/ #MERFISH) and during human hematopoiesis. 1/3 nature.com/articles/s4158…

Heading to #ISMB2024 in Montreal. Looking forward to meet everyone who are around!

Excited to share the white paper for the IGVF Consortium, supported by National Human Genome Research Institute Deciphering the impact of genomic variation on function rdcu.be/dSZdm

I met so many people (students, researchers, and even investors) say they are so interested in understanding intelligence. Yet, they never bother to prepare themselves with the basic mathematical background. They wouldn't be able to understand anything even if a perfect theory is

Great lab to join! Darko's lab has a lot of cool single cell multiome data to understand the role of chromatin remodelers in boold cancers! Great potential for high-impact research plus he is very insightful and kind mentor!

Enjoyed the talks and meeting the old and new friends at #SCG2024. Huge thanks for the organizers!

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

ChromaFold is out! Very effective and robust model to predict 3D contact maps from scATAC-seq.

Delighted to have worked on this perspective on the cis-regulatory code with Julia Zeitlinger (@[email protected]), Jason Ernst Lab, Ferhat Ay, Anthony Mathelier, Alejandra Medina-Rivera, Shaun Mahony, Saurabh Sinha arxiv.org/abs/2411.04363. We provide an overview of current progress and some challenges to think about.

My goal is to understand the regulatory role of every nucleotide in the genome, and how this changes across every cell in the human body. If you are interested in doing a Ph.D. with me UMass Chan Genomics and Computational Biology, see the links below. Deadline is Dec 1st.

Introducing scE2G: a new model to link enhancers to target genes using single-cell data. Excited that scE2G will enable building enhancer maps in hundreds of cell types in the human body! Wonderful collaboration with Robin Andersson Wei-Lin Qiu maya sheth and others 👇

Happy to share HiC2Self, a self-supervised tool for denoising bulk and single-cell Hi-C contact maps! biorxiv.org/content/10.110…

Please connect here: bsky.app/profile/karbal…

We are hiring 🎺🎺🎺! As part of our immuno-oncology transformation Memorial Sloan Kettering Cancer Center we are building the Computational Immuno-Oncology Shared Resource. CIOSR is a key pillar supporting expanded immune monitoring & broad IO efforts. We have two open positions: bioinformatics

[SAVE THE DATE] MLCB 2025 is happening Sep 10-11 at the NY Genome Center—NYC! Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections! Submission deadline: Jun 1 Details: mlcb.github.io Spread the word—please RT!

Looks like a great venue!

Great opportunity!

Great workshop and fantastic talks!

Our paper is now in Nature Biotechnology! Topological velocity inference from spatial transcriptomic data. TopoVelo infers the direction of differentiation/migration; quantifies spatial cell influence; and identifies morphology changes during differentiation. 🧵rdcu.be/ewqMB