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Delighted to see not one, not two, but three papers about astrocytes in Science today! Here's our contribution to that collection. Come follow us on bluesky! Papouin lab twitter/X: over & out... science.org/doi/10.1126/sc…

Online now! Rowan Saloner et al. used large-scale CSF proteomics to uncover molecular signatures in frontotemporal dementia, revealing RNA splicing and synaptic protein candidate markers for genetic and sporadic disease progression. UCSF MAC ALLFTD doi.org/10.1038/s43587…

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: Immunity cell.com/immunity/fullt…

Neuron Cell Reports Cell Reports Methods USBrainAlliance Specific targeting of brain endothelial cells using enhancer AAV vectors cell.com/neuron/fulltex… Neuron

Neuron Cell Reports Cell Reports Methods USBrainAlliance An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons cell.com/cell-reports-m… Cell Reports Methods

Deep canvassing creates opportunities for change. These conversations our field team has moves people — we've seen it. We want you to join us. We need you to join us. Sign our Pledge to Defend Trans Rights: mobilize.us/promomissouri/…

Lemborexant, a dual orexin receptor antagonist, ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy nature.com/articles/s4159…

New TYP lab publication led by PhD student Alex Lish out today in Cell Reports! We present a reproducible neuron-astrocyte-microglia tri-culture model to study intercellular interactions in Alzheimer's disease. Read more here: cell.com/cell-reports/f…

🎉 New paper alert! Congrats Courtney Lane-Donovan and team on the latest publication in Alzheimer’s & Dementia: "Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases" 🧠🧪alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… #Neuroscience #CWOW

Pre-print alert on #tangle maturity in #Alzheimers ✅ 15 #tau antibodies ✅ human #hippocampus ✅ manual tangle maturity scale ✅ #pathomics approach to automate ✅ neuritic and tangle-bearing tau biorxiv.org/content/10.110… If you have not checked out Google's NotebookLM ,

Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?

Microglial STING is a central safeguard against neurological decline with age: Cell Reports cell.com/cell-reports/f…

Do you care about #Alzheimer disease research (or research on human diseases generally)? Some of the best scientists in the field are at universities that have received no NIH funding since April, with no end in sight. grant-watch.us/posts/trends-i…

WashU Medicine continues to unite the world’s most innovative researchers. We’re proud to introduce Jennifer Phillips-Cremins, PhD, to our team — a global leader in 3D genome structure and its role in brain development and healthy function. source.washu.edu/2025/06/philli…

Excited to share a new preprint out from the lab (biorxiv.org/content/10.110…) by 1st-author Brittany Hemmer , a newly minted PhD from the lab! A brief thread on what we found (1/n):

Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases | Science Signaling science.org/doi/10.1126/sc…

Neurons are cool, but do you work with something cooler and understudied like the Blood-Brain Barrier? As a Guest Editor, I invite you to submit manuscripts in the Brain-Immune-Vascular interface for NPJ Dementia! More info at: nature.com/collections/ih… #Neuroscience #Alzheimer

The Celeste Karch demonstrate that MAPT mRNA and tau protein are expressed in microglia in human brains and in hiPSC-derived #microglia like cells. 🧠 💡Learn more in their new molecularpsychiatry study: go.nature.com/447xVwS