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New preprint: Cyanobacteria isolated from marine volcanic seeps display rapid sinking and robust, high density growth. Thanks to U Palermo and Two Frontiers Project, we got unique samples from Vulcano, Italy, where CO2 bubbles into the shallow ocean, 24-7! biorxiv.org/content/10.110…

💻🧫New preprint: How accurately can we predict diverse phage bacteria-interactions from their genomes only ? We created a matrix of >38k phage-bacteria interactions to find out (=> AUROC 86%) & used our predictions to recommend tailored phage cocktails. biorxiv.org/content/10.110…

New Preprint, New Retrons! More than a hundred of them. We synthesized a ton of bioinformatically predicted retrons and put them through a battery of tests, from RT-DNA production to editing in human cells, E. coli, and phage biorxiv.org/content/10.110… Gladstone Institutes UC San Francisco UCSF Bioengineering & Therapeutic Sciences

In our article published today nature , we report complete all-atom structural models of a fully packaged bacteriophage particle. Congratulations to Kush Coshic on his first publication! Many thanks to Chris Maffeo and David Winogradoff for pushing this 6-year project forward.

Multitrons: simultaneous multi-site editing of individual genomes using retron arrays, now published in Nature Chemical Biology Nature Chemical Biology: nature.com/articles/s4158…. Great job Alex González-Delgado and oso !

A Lego I would like to make Engineering tailocins Dorien Dams #PhgOx24 Bacteriophage Oxford

Multiplexed editing of phage genomes using retrons, now published at Nature Biotechnology with lots of new bells and whistles. chloe kate crawford Santi Bhattarai-Kline Darshini Poola Karen Zhang Alex González-Delgado Matías Rojas Montero nature.com/articles/s4158…

University of Washington biochemist David Baker has won the 2024 Nobel Prize in Chemistry for his pioneering work designing new proteins that can neutralize viruses, target cancer cells, and more. Read more from @uwmedicine: go.uw.edu/2024NobelPrize #NobelPrize #GoHuskies

My PhD advisor, David Baker, just won the Nobel Prize! 🎉 He is an inspirational scientific leader who not only does groundbreaking research but has also built an enduring, supportive community. Most importantly, he’s a genuinely kind human being. Congratulations David! I am so

We are so excited to be joining the Arc family!

Save the date for the 2025 symposium on the immune system of bacteria: April 8-10 in Paris, France Registration opens in two weeks. A fantastic lineup of speakers!

Phage vs. Bacteria: New findings! Phages use their own tRNAs to evade bacterial defenses like retrons and PrrC. Huge thanks to Azam for his hard work! in Nature Communications nature.com/articles/s4146…

This is a foundational achievement. MMseqs2-GPU virtually *erases* the bottleneck of homology search in many workflows, including structure prediction. Christian Dallago @milot_mirdita @thesteinegger, Felix, Bertil, and Alejandro too! developer.nvidia.com/blog/boost-alp…