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We're hiring early career researchers! Come join our awesome team working to improve immunotherapy and cure cancer. Learn more here: mangusolab.org/join

Our manuscript on targeting TBK1 to overcome resistance to ICB with the Jenkins lab Mass General Cancer Center is out online today in nature. Thrilled to have been part of this amazing collaboration lead by Yi Sun, Or-Yam Revach, and the Jenkins lab. More to come. nature.com/articles/s4158…

Researchers from the Broad, AbbVie, & Calico Life Sciences are developing a new small-molecule cancer immunotherapy candidate — now being tested in an early-stage clinical trial — that may provoke a powerful dual response in both cancer & immune cells. broad.io/TIDE-PTPN2-news

The Tumor Immunotherapy Discovery Engine, or TIDE, aims to systematically identify the genes tumors use to evade the immune system — and make cancer immunotherapy more effective. Learn more in a new feature story: broad.io/TIDE-feature and video: broad.io/TIDE-video.

Congrats to Zuzana Tothova, MD, PhD (@TothovaLab) who is the recipient of the Doris Duke Foundation's Paragon Award for Research Excellence! “Receiving the Paragon Award means the world to me. I am extremely honored and very touched by this recognition,” said Tothova.

Love this new tech to rapidly generate and test new CRISPR plasmids!

I don't know who's more excited, Meng-Ju Wu or me! Looking forward to future collaborations and grateful this brilliant scientist is staying close by.

🔥Just published! What are the principles of plasticity in cancer cells? Studying 7 cancer types we propose that developmental constraints restrict transitions to progenitor & differentiated-like states of adjacent lineages. authors.elsevier.com/a/1jDHoL7PXqQdg Cell Ayushi Patel

New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n

Ferry service may experience minor delays through tomorrow, August 15, due to the presence of a juvenile humpback whale in Boston Harbor.

If you're looking for a postdoc or technician position in cancer immunology, please consider applying. There's something really special about being one of the first hires in an exciting new lab!

This is a huge deal. “Indirect costs”, as they’re called, from NIH still pay for direct science — eg, funding science labs, lab upkeep — but also university administration. Cutting this line item by billions of dollars is going to threaten university jobs but also potentially

How to decimate US #Science and cede leadership to China - NIH plans to slash support for indirect research costs, sending shockwaves through science statnews.com/2025/02/07/nih…

The Department of Health and Human Services has pressed the NIH to ignore court orders, dismissing NIH lawyers' advice to resume business as usual, @katherinejwu reports. As of this week, some institutes and centers are still not issuing any new grants: theatlantic.com/health/archive…

Parts and ICRAFTs: Finding new immunotherapy targets dlvr.it/TJXr0s

Llamas, dolphins and measles? Oh my! So thankful this story is finally breaking containment from my time in the Rob Manguso. Using pieces from viruses and llamas we engineered selective cell specific viral like particles with reduced immunogenicity for in vivo gene delivery