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📢For all HaloTag lovers💙💚❤💜🤍 we developed a new cell-permeable Biotin-HaloTag ligand enabling rapid protein labeling in living cells and efficient streptavidin pull-down. We hope you enjoy the reading and find some inspiration🙌 biorxiv.org/content/10.110…

Our paper was published in nature. We discovered a new aspect of the meiotic homolog pairing process named Rapid Homolog Juxtaposition (RHJ). During RHJ, homologous loci undergo spatial juxtaposition from far apart to very close together in a short time. nature.com/articles/s4158…

Thrilled to share our new work bioRxiv: biorxiv.org/content/10.110… Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2

Katsuhiko Minami et al. have quantitatively measured nucleosome motion in the four chromatin classes from euchromatin to heterochromatin. More euchromatic regions (earlier replicated regions) show greater nucleosome motion. 2/2 biorxiv.org/content/10.110…

Glad to share our work bioRxiv, which enabled euchromatin/heterochromatin-specific single-nucleosome imaging! I want to express my deepest gratitude to my supervisor Kazuhiro Maeshima, all the co-authors, and Maeshima-lab members. Proud to have been involved in this work.

Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography biorxiv.org/cgi/content/sh… #biorxiv_biophys

🦋 katsuminami.bsky.social

Our new review on how the #chromatin domain is formed in the cell is out @ Curr Opin Struct Biol.📄✨ We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation. 📥 Free-download link: authors.elsevier.com/a/1keGn,LqArXq…

My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.110… Huge thanks to my PI, Kazuhiro Maeshima, for supervision. Amazing collab with Rosana Collepardo’s group!" (1/n)

Our new preprint is out＠bioRxiv: biorxiv.org/content/10.110… Masa A. Shimazoe et al. reveal that linker histone H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with Rosana Collepardo, Charlie Phillips, Jan Huertas and others—huge thanks! 🙌 1/2

Our new paper is out Science Advances👇 science.org/doi/10.1126/sc… 🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells. 🔍Katsuhiko Minami et al.have developed a chromatin behavior atlas within the nucleus. 1/2

We quantitatively measured nucleosome motion across the 4 chromatin classes, from euchromatin to heterochromatin. 🧪 More euchromatic regions (i.e., earlier-replicated regions) show greater nucleosome motion. 🎉 Congrats Katsuhiko Minami and all collaborators! 2/2

🧬My retrospective chromatin review is out@Proc Jpn Acad: doi.org/10.2183/pjab.1… Textbook models of 30-nm fibers are fading. A new paradigm: chromatin forms liquid-like domains—locally dynamic, yet globally stable at chromosome level (viscoelastic)—supporting genome function.✨

Our new review paper is out @ JMB!　🧬 Katsuhiko Minami Adilgazy Semeigazin, MSc よしこりあん discuss DNA accessibility in euchromatin and heterochromatin in living cells. 📘 Free access: authors.elsevier.com/a/1lHgb54HFZNbb 🔗 Also, check our previous paper on nucleosome motion: science.org/doi/10.1126/sc…

Our new work bioRxiv 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. Adilgazy Semeigazin, MSc Katsuhiko Minami Masa A. Shimazoe

Our latest preprint is posted on bioRxiv Cell Biology. Big congratulations to Adilgazy Semeigazin, MSc and all the co-authors!

Along with my recent first-author publication in J Cell Science , I was also featured in their interview series “First Person”, where I shared a bit about my research journey.

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior. Congratulations Jing! Happy to have contributed in a small way to this interesting work! nature.com/articles/s4146…